On MSE-optimal crossover designs

DOI10.1214/17-AOS1644MaRDI QIDQ1991683zbMATH OpenOpenAlexFDO

Authors Christoph Neumann, Joachim Kunert

Publication date 30 October 2018

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://projecteuclid.org/euclid.aos/1536307238

zbMATH Keywords

crossover designMSE-optimalityoptimal design

Mathematics Subject Classification ID

Optimal statistical designs (62K05) Statistical block designs (62K10)

Review text

A crossover design is a repeated measurements design such that each experiment unit (e.g. the patient) receives different treatments during the different time periods, i.e. the patient crosses over from one treatment to another during the course of the trial. Often a treatment applied in a given period has in addition to its direct effect a so-called carryover effect, i.e. it may effect the measurement in the next period. Most papers on optimal crossover designs consider an estimate which is corrected for carryover effects. However, this corrected estimate has a large variance. In this paper the authors consider another way. They use the uncorrected estimate which has a smaller variance but which is biased if carryover effects cannot be neglected. They find crossover designs which are optimal in the sense that they minimize the mean squared error (MSE), i.e. the sum of variance and bias. Efficiency considerations show that often designs which are optimal for the corrected estimate are also efficient for the uncorrected estimate.

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Cites work

• Balanced repeated measurements designs
• Crossover designs
• scientific article; zbMATH DE number 3490283 (Why is no real title available?)
• scientific article; zbMATH DE number 6125590 (Why is no real title available?)
• Optimal and Efficient Repeated-Measurements Designs for Uncorrelated Observations
• Optimal design and refinement of the linear model with applications to repeated measurements designs
• Optimal repeated measurements designs: The linear optimality equations
• Optimality of neighbour balanced designs when neighbour effects are neglected
• Theory of optimal designs

Cited in

(3)

• On MSE-optimal circular crossover designs
• On Variance Estimation in Crossover Designs
• An exact upper limit for the variance bias in a carry-over model with correlated errors

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