Enhancement of chemotherapy using oncolytic virotherapy: mathematical and optimal control analysis
From MaRDI portal
Publication:2000772
Abstract: Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects. To investigate how OV could enhance chemotherapy, we propose an ODE based model describing the interactions between tumour cells, the immune response, and a treatment combination with chemotherapy and oncolytic viruses. Stability analysis of the model with constant chemotherapy treatment rates shows that without any form of treatment, a tumour would grow to its maximum size. It also demonstrates that chemotherapy alone is capable of clearing tumour cells provided that the drug efficacy is greater than the intrinsic tumour growth rate. Furthermore, OV alone may not be able to clear tumour cells from body tissue but would rather enhance chemotherapy if viruses with high viral potency are used. To assess the combined effect of OV and chemotherapy we use the forward sensitivity index to perform a sensitivity analysis, with respect to chemotherapy key parameters, of the virus basic reproductive number and the tumour endemic equilibrium. The results from this sensitivity analysis indicate the existence of a critical dose of chemotherapy above which no further significant reduction in the tumour population can be observed. Numerical simulations show that a successful combinational therapy of the chemotherapeutic drugs and viruses depends mostly on the virus burst size, infection rate, and the amount of drugs supplied. Optimal control analysis was performed, by means of Pontryagin's principle, to further refine predictions of the model with constant treatment rates by accounting for the treatment costs and sides effects.
Recommendations
- Modelling the spatiotemporal dynamics of chemovirotherapy cancer treatment
- A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma
- Mathematical model of optimal chemotherapy and oncolytic virotherapy
- Modeling treatment of cancer using oncolytic virotherapy with saturated incidence
- Modeling the spatiotemporal dynamics of oncolytic viruses and radiotherapy as a treatment for cancer
Cites work
- scientific article; zbMATH DE number 5991335 (Why is no real title available?)
- scientific article; zbMATH DE number 3505708 (Why is no real title available?)
- A chemotherapy model for the treatment of cancer with metastasis
- A mathematical model for cell cycle-specific cancer virotherapy
- A mathematical model for the effect of anti-angiogenic therapy in the treatment of cancer tumours by chemotherapy
- A mathematical model of chemotherapy response to tumour growth
- A mathematical model of vascular tumor treatment by chemotherapy
- A model of HIV-1 infection with HAART therapy and intracellular delays
- Analysis of virotherapy in solid tumor invasion
- Lytic cycle: A defining process in oncolytic virotherapy
- Mathematical model creation for cancer chemo-immunotherapy
- Modeling immunotherapy of the tumor -- immune interaction
- Modeling of cancer virotherapy with recombinant measles viruses
- Modelling the spatiotemporal dynamics of chemovirotherapy cancer treatment
- Optimal control of the dynamics of a tumor growth model with Hollings' type-II functional response
- Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
- Some mathematical models for cancer chemotherapy
- Stability and bifurcation analysis of delay induced tumor immune interaction model
- The replicability of oncolytic virus: defining conditions in tumor virotherapy
Cited in
(22)- Dampening effects on global boundedness in a quartic haptotactic model with fusogenic oncolytic virus and syncytia
- Optimal control of effector-tumor-normal cells dynamics in presence of adoptive immunotherapy
- Modelling the spatiotemporal dynamics of chemovirotherapy cancer treatment
- Modeling the effect of contaminated objects for the transmission dynamics of COVID-19 pandemic with self protection behavior changes
- Global dynamics of reaction-diffusion oncolytic M1 virotherapy with immune response
- Hopf bifurcation on a cancer therapy model by oncolytic virus involving the malignancy effect and therapeutic efficacy
- On the treatment of melanoma: a mathematical model of oncolytic virotherapy
- Optimization of virotherapy for cancer
- Computational modeling of cancer response to oncolytic virotherapy: improving the effectiveness of viral spread and anti tumor efficacy
- scientific article; zbMATH DE number 6321535 (Why is no real title available?)
- Mathematical model of optimal chemotherapy and oncolytic virotherapy
- A general non-local delay model on oncolytic virus therapy
- Combination of virotherapy and chemotherapy with optimal control for combating cancer
- Oncolytic viral therapies and the delicate balance between virus-macrophage-tumour interactions: a mathematical approach
- Analysis of a delayed and diffusive oncolytic M1 virotherapy model with immune response
- A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept
- A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma
- Modeling the virus-induced tumor-specific immune response with delay in tumor virotherapy
- Modeling the effect of vaccination and treatment on the transmission dynamics of hepatitis B virus and HIV/AIDS coinfection
- Boundedness in a haptotactic cross-diffusion system modeling oncolytic virotherapy
- Control analysis of virotherapy chaotic system
- Mathematical analysis of a mathematical model of chemovirotherapy: effect of drug infusion method
This page was built for publication: Enhancement of chemotherapy using oncolytic virotherapy: mathematical and optimal control analysis
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2000772)
