Identifiability from a few species for a class of biochemical reaction networks

DOI10.1007/S11538-019-00594-0zbMATH Open1417.92064arXiv1811.08336OpenAlexW2926469103WikidataQ92836221 ScholiaQ92836221MaRDI QIDQ2002101FDOQ2002101

Pablo Solernó, Gabriela Jeronimo, Mercedes Pérez Millán

Publication date: 11 July 2019

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: Under mass-action kinetics, biochemical reaction networks give rise to polynomial autonomous dynamical systems whose parameters are often difficult to estimate. We deal in this paper with the problem of identifying the kinetic parameters of a class of biochemical networks which are abundant, such as multisite phosphorylation systems and phosphorylation cascades (for example, MAPK cascades). For any system of this class we explicitly exhibit a single species for each connected component of the associated digraph such that the successive total derivatives of its concentration allow us to identify all the parameters occurring in the component. The number of derivatives needed is bounded essentially by the length of the corresponding connected component of the digraph. Moreover, in the particular case of the cascades, we show that the parameters can be identified from a bounded number of successive derivatives of the last product of the last layer. This theoretical result induces also a heuristic interpolation-based identifiability procedure to recover the values of the rate constants from exact measurements.

Full work available at URL: https://arxiv.org/abs/1811.08336

zbMATH Keywords

identifiabilitychemical reaction networksmass-action kineticsMAPK cascade

Mathematics Subject Classification ID

Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cited In (2)

• Identifiability of chemical reaction networks
• Weak identifiability for differential algebraic systems

Uses Software

• Maple
• BLAD
• DAISY
• GenSSI
• COMBOS
• MESSI
• ObservabilityTest
• SIAN

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