On the relation between reactions and complexes of (bio)chemical reaction networks
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Publication:2013286
Abstract: Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the stoichiometry of the underlying interrelated components, but also on a multitude of kinetic parameters. Invariant flux ratios, obtained within flux coupling analysis, as well as invariant complex ratios, derived within chemical reaction network theory, can characterize robust properties of a system at steady state. However, the existing formalisms for the description of these invariants do not provide full characterization as they either only focus on the flux-centric or the concentration-centric view. Here we develop a novel mathematical framework which combines both views and thereby overcomes the limitations of the classical methodologies. Our unified framework will be helpful in analyzing biologically important system properties.
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Cites work
- scientific article; zbMATH DE number 1090658 (Why is no real title available?)
- Chemical reaction systems with toric steady states
- Ideals, varieties, and algorithms. An introduction to computational algebraic geometry and commutative algebra
- The existence and uniqueness of steady states for a class of chemical reaction networks
Cited in
(9)- Absolute concentration robustness in networks with low-dimensional stoichiometric subspace
- On the complexity of reconstructing chemical reaction networks
- Reaction network realizations of rational biochemical systems and their structural properties
- Network translation and steady-state properties of chemical reaction systems
- A mathematical approach to emergent properties of metabolic networks: partial coupling relations, hyperarcs and flux ratios
- Absolute concentration robustness: algebra and geometry
- Conditions for duality between fluxes and concentrations in biochemical networks
- Biochemical reaction networks: An invitation for algebraic geometers
- Chemical reaction network approaches to biochemical systems theory
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