A bioequivalence test by the direct comparison of concentration-versus-time curves using local polynomial smoothers

DOI10.1155/2016/4680642MaRDI QIDQ2013948zbMATH OpenOpenAlexWikidataFDO

Authors Suyan Tian, Howard H. Chang, Dana Orange, Jingkai Gu, Mayte Suárez Fariñas

Publication date 10 August 2017

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2016/4680642

zbMATH Keywords

bioequivalence testlocal polynomial smootherspharmacokinetic parameters

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Applications of statistics to biology and medical sciences; meta analysis (62P10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Recommendations

• The multivariate assessment of bioequivalence
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• On a multivariate test for bioequivalence
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Cites work

• Bandwidth selection: Classical or plug-in?
• Bootstrap methods: another look at the jackknife
• Longitudinal data analysis using generalized linear models
• On equivalence and bioequivalence testing
• Permutation, parametric and bootstrap tests of hypotheses.
• Robust Locally Weighted Regression and Smoothing Scatterplots
• Statistical tests for multivariate bioequivalence
• Variable bandwidth and local linear regression smoothers

Describes a project that uses

Uses Software

• DEseq

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