A mathematical model for fluid-glucose-albumin transport in peritoneal dialysis

DOI10.2478/AMCS-2014-0062zbMATH Open1309.93022arXiv1310.5876OpenAlexW3103899012MaRDI QIDQ2018410FDOQ2018410

Authors: Joanna Stachowska-Piętka, Jacek Waniewski, Roman Cherniha 

Publication date: 14 April 2015

Published in: International Journal of Applied Mathematics and Computer Science (Search for Journal in Brave)

Abstract: A mathematical model for fluid and solute transport in peritoneal dialysis is constructed. The model is based on a three-component nonlinear system of two-dimensional partial differential equations for fluid, glucose and albumin transport with the relevant boundary and initial conditions. Its aim is to model ultrafiltration of water combined with inflow of glucose to the tissue and removal of albumin from the body during dialysis, and it does this by finding the spatial distributions of glucose and albumin concentrations and hydrostatic pressure. The model is developed in one spatial dimension approximation and a governing equation for each of the variables is derived from physical principles. Under certain assumptions the model are simplified with the aim of obtaining exact formulae for spatially non-uniform steady-state solutions. As the result, the exact formulae for the fluid fluxes from blood to tissue and across the tissue are constructed together with two linear autonomous ODEs for glucose and albumin concentrations in the tissue. The obtained analytical results are checked for their applicability for the description of fluid-glucose-albumin transport during peritoneal dialysis.

Full work available at URL: https://arxiv.org/abs/1310.5876

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zbMATH Keywords

ordinary differential equationnonlinear partial differential equationsteady-state solutionfluid transporttransport in peritoneal dialysis

Mathematics Subject Classification ID

Medical applications (general) (92C50) Nonlinear systems in control theory (93C10) Control/observation systems governed by ordinary differential equations (93C15)

Cites Work

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• A mathematical model for fluid-glucose-albumin transport in peritoneal dialysis
• Mathematical modeling of biological systems. Vol. I: Cellular biophysics, regulatory networks, development, biomedicine, and data analysis. Selected papers based on the presentations at the European conference on mathematical and theoretical biology, (ECMTB05), Dresden, Germany, July 2005.
• Physiological Interpretation of Solute Transport Parameters for Peritoneal Dialysis
• Exact Solutions of a Mathematical Model for Fluid Transport in Peritoneal Dialysis

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