A mathematical model of p62-ubiquitin aggregates in autophagy

DOI10.1007/S00285-021-01659-2zbMATH Open1480.92071arXiv2004.07926OpenAlexW3017374434WikidataQ113905469 ScholiaQ113905469MaRDI QIDQ2067652FDOQ2067652

Authors: Julia Delacour, M. Doumic, Sascha Martens, Christian Schmeiser, Gabriele Zaffagnini 

Publication date: 18 January 2022

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Aggregation of ubiquitinated cargo by oligomers of the protein p62 is an important preparatory step in cellular autophagy. In this work a mathematical model for the dynamics of these heterogeneous aggregates in the form of a system of ordinary differential equations is derived and analyzed. Three different parameter regimes are identified, where either aggregates are unstable, or their size saturates at a finite value, or their size grows indefinitely as long as free particles are abundant. The boundaries of these regimes as well as the finite size in the second case can be computed explicitly. The growth in the third case (quadratic in time) can also be made explicit by formal asymptotic methods. The qualitative results are illustrated by numerical simulations. A comparison with recent experimental results permits a partial parametrization of the model.

Full work available at URL: https://arxiv.org/abs/2004.07926

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Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60) Cell biology (92C37)

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