A mathematical model of p62-ubiquitin aggregates in autophagy

DOI10.1007/S00285-021-01659-2MaRDI QIDQ2067652zbMATH OpenOpenAlexWikidataFDO

Authors Julia Delacour, M. Doumic, Sascha Martens, Christian Schmeiser, Gabriele Zaffagnini

Publication date 18 January 2022

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2004.07926

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Qualitative investigation and simulation of ordinary differential equation models (34C60) Cell biology (92C37)

Abstract: Aggregation of ubiquitinated cargo by oligomers of the protein p62 is an important preparatory step in cellular autophagy. In this work a mathematical model for the dynamics of these heterogeneous aggregates in the form of a system of ordinary differential equations is derived and analyzed. Three different parameter regimes are identified, where either aggregates are unstable, or their size saturates at a finite value, or their size grows indefinitely as long as free particles are abundant. The boundaries of these regimes as well as the finite size in the second case can be computed explicitly. The growth in the third case (quadratic in time) can also be made explicit by formal asymptotic methods. The qualitative results are illustrated by numerical simulations. A comparison with recent experimental results permits a partial parametrization of the model.

Recommendations

• Computer simulations unveil the dynamics of autophagy and its implications for the cellular quality control
• A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentation
• A study in nucleated polymerization models of protein aggregation
• A mathematical model of cell population dynamics with autophagy response to starvation
• Mathematical aspects of the kinetics of formation and degradation of linear peptide or protein aggregates

Cites work

• Existence, Uniqueness and Mass Conservation for the Coagulation-Fragmentation Equation
• From the discrete to the continuous coagulation–fragmentation equations
• Introduction to Random Graphs
• On a coagulation and fragmentation equation with mass loss
• The Beker--Döring System and Its Lifshitz--Slyozov Limit

Cited in

(3)

• Computer simulations unveil the dynamics of autophagy and its implications for the cellular quality control
• A hybrid model of molecular regulation and population dynamics for yeast autophagy
• Dynamic scaling of lipofuscin deposition in aging cells

This page was built for publication: A mathematical model of p62-ubiquitin aggregates in autophagy

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2067652)