Reduction of a model for sodium exchanges in kidney nephron

DOI10.3934/NHM.2021020zbMATH Open1481.35027arXiv2005.07419OpenAlexW3179856215MaRDI QIDQ2070540FDOQ2070540

Authors: Marta Marulli, Vuk Milišić, Nicolas Vauchelet 

Publication date: 24 January 2022

Published in: Networks and Heterogeneous Media (Search for Journal in Brave)

Abstract: This work deals with a mathematical analysis of sodium's transport in a tubular architecture of a kidney nephron. The nephron is modelled by two counter-current tubules. Ionic exchange occurs at the interface between the tubules and the epithelium and between the epithelium and the surrounding environment (interstitium). From a mathematical point of view, this model consists of a 5x5 semi-linear hyperbolic system. In the literature similar models neglect the epithelial layers. In this paper, we show rigorously that such models may be obtained by assuming that the permeabilities between lumen and epithelium are large. Indeed we show that when these grow, solutions of the 5x5 system converge in a certain way to solutions of a reduced 3x3 system where no epithelial layer is present. The problem is dened on a bounded spacial domain with initial and boundary data. Establishing BV compactness forces to introduce initial layers and to handle carefully the presence of lateral boundaries.

Full work available at URL: https://arxiv.org/abs/2005.07419

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zbMATH Keywords

boundary layershyperbolic systemscharacteristics methodionic exchangesrelaxation limit

Mathematics Subject Classification ID

Systems biology, networks (92C42) Singular perturbations in context of PDEs (35B25) Initial-boundary value problems for first-order hyperbolic systems (35L50) First-order nonlinear hyperbolic equations (35L60) Singular hyperbolic equations (35L81)

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Cited In (3)

• On the role of the epithelium in a model of sodium exchange in renal tubules
• Title not available (Why is that?)
• Title not available (Why is that?)

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