Reduction of a model for sodium exchanges in kidney nephron

DOI10.3934/NHM.2021020MaRDI QIDQ2070540zbMATH OpenOpenAlexFDO

Authors Marta Marulli, Vuk Milišić, Nicolas Vauchelet

Publication date 24 January 2022

Published in Networks and Heterogeneous Media (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2005.07419

zbMATH Keywords

boundary layershyperbolic systemscharacteristics methodionic exchangesrelaxation limit

Mathematics Subject Classification ID

Systems biology, networks (92C42) Singular perturbations in context of PDEs (35B25) Initial-boundary value problems for first-order hyperbolic systems (35L50) First-order nonlinear hyperbolic equations (35L60) Singular hyperbolic equations (35L81)

Abstract: This work deals with a mathematical analysis of sodium's transport in a tubular architecture of a kidney nephron. The nephron is modelled by two counter-current tubules. Ionic exchange occurs at the interface between the tubules and the epithelium and between the epithelium and the surrounding environment (interstitium). From a mathematical point of view, this model consists of a 5x5 semi-linear hyperbolic system. In the literature similar models neglect the epithelial layers. In this paper, we show rigorously that such models may be obtained by assuming that the permeabilities between lumen and epithelium are large. Indeed we show that when these grow, solutions of the 5x5 system converge in a certain way to solutions of a reduced 3x3 system where no epithelial layer is present. The problem is dened on a bounded spacial domain with initial and boundary data. Establishing BV compactness forces to introduce initial layers and to handle carefully the presence of lateral boundaries.

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Cites work

• scientific article; zbMATH DE number 3868094 (Why is no real title available?)
• scientific article; zbMATH DE number 52582 (Why is no real title available?)
• scientific article; zbMATH DE number 1849082 (Why is no real title available?)
• A simple derivation of BV bounds for inhomogeneous relaxation systems
• Analysis of a simplified model of the urine concentration mechanism
• CONVERGENCE OF A RELAXATION APPROXIMATION TO A BOUNDARY VALUE PROBLEM FOR CONSERVATION LAWS
• Convergence Results for Some Conservation Laws with a Reflux Boundary Condition and a Relaxation Term Arising in Chemical Engineering
• Hyperbolic Conservation Laws in Continuum Physics
• Mathematical modeling in renal physiology
• On the asymptotic regime of a model for friction mediated by transient elastic linkages
• On the role of the epithelium in a model of sodium exchange in renal tubules
• Relaxation limit and initial-layers for a class of hyperbolic-parabolic systems
• The relaxation schemes for systems of conservation laws in arbitrary space dimensions
• Topologies and measures on the space of functions of bounded variation taking values in a Banach or metric space
• Transport equations in biology.
• Weakly Differentiable Functions

Cited in

(3)

• On the role of the epithelium in a model of sodium exchange in renal tubules
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