Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes

DOI10.1515/RNAM-2022-0025MaRDI QIDQ2094907zbMATH OpenOpenAlexFDO

Authors V. F. Sokolov

Publication date 8 November 2022

Published in Russian Journal of Numerical Analysis and Mathematical Modelling (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1515/rnam-2022-0025

zbMATH Keywords

dynamicsordinary differential equationsmathematical modellingsystems analysisquantitative systems pharmacology

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) General systems (93A10) Pathology, pathophysiology (92C32)

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Cites work

• scientific article; zbMATH DE number 3538668 (Why is no real title available?)
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy
• Mathematical modelling of the intravenous glucose tolerance test

Cited in

(5)

• Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes
• Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model
• Challenges in pharmacology modelling
• scientific article; zbMATH DE number 5510632 (Why is no real title available?)
• Applying quantitative systems pharmacology (QSP) modeling to understand the treatment of \textit{Pneumocystis}

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Uses Software

• Monolix

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