Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes

DOI10.1515/RNAM-2022-0025zbMATH Open1504.92038OpenAlexW4308447823MaRDI QIDQ2094907FDOQ2094907

Authors: V. F. Sokolov 

Publication date: 8 November 2022

Published in: Russian Journal of Numerical Analysis and Mathematical Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/rnam-2022-0025

Recommendations

• Topics in mathematical pharmacology
• Challenges in pharmacology modelling
• A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment
• Applying quantitative systems pharmacology (QSP) modeling to understand the treatment of \textit{Pneumocystis}
• Development of a computational model of glucose toxicity in the progression of diabetes mellitus

zbMATH Keywords

dynamicsordinary differential equationsmathematical modellingsystems analysisquantitative systems pharmacology

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) General systems (93A10) Pathology, pathophysiology (92C32)

Cites Work

• Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy
• Title not available (Why is that?)
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Mathematical modelling of the intravenous glucose tolerance test

Cited In (5)

• Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes
• Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model
• Challenges in pharmacology modelling
• Title not available (Why is that?)
• Applying quantitative systems pharmacology (QSP) modeling to understand the treatment of \textit{Pneumocystis}

Uses Software

• Monolix

This page was built for publication: Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2094907)