A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response

DOI10.1016/J.JTBI.2022.111293MaRDI QIDQ2095409zbMATH OpenOpenAlexFDO

Authors Andreas C. Aristotelous, M. Gregory Forest, Alex W. J. Chen

Publication date 9 November 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111293

zbMATH Keywords

COVID-19simulationscellular automatoninnate immunitypneumonia

Mathematics Subject Classification ID

Biology and other natural sciences (92-XX)

Cites work

• scientific article; zbMATH DE number 3463051 (Why is no real title available?)
• scientific article; zbMATH DE number 3892344 (Why is no real title available?)
• A novel time integration method for solving a large system of non-linear algebraic equations
• Chemical evolutionary games
• Direct Methods for Sparse Linear Systems
• Fingering in Stochastic Growth Models

Cited in

(2)

• A low dimensional dynamical model of the initial pulmonary innate response to infection
• Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

Describes a project that uses

Uses Software

• CSparse

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