A mathematical model of the within-host kinetics of SARS-CoV-2 neutralizing antibodies following COVID-19 vaccination

DOI10.1016/J.JTBI.2022.111280MaRDI QIDQ2109238zbMATH OpenOpenAlexFDO

Authors Lisette De Pillis, Rebecca Caffrey, Ge Chen, Mark D. Dela, Leif Eldevik, Joseph McConnell, Shahrokh Shabahang, Stephen A. Varvel

Publication date 20 December 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111280

zbMATH Keywords

AditxtScore\texttrademarkCOVID-19host-specific parameter fittingmathematical modelneutralizing antibody NAbSARS-CoV-2vaccinationwithin-host model

Mathematics Subject Classification ID

Mathematical modeling or simulation for problems pertaining to biology (92-10) Medical epidemiology (92C60)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• An adaptive Metropolis algorithm
• Malaria and COVID-19 co-dynamics: a mathematical model and optimal control
• Mathematical analysis of a within-host model of SARS-CoV-2
• Matlab
• Multi-method global sensitivity analysis of mathematical models
• Optimization Toolbox
• The within-host viral kinetics of SARS-CoV-2
• To Sobol or not to Sobol? The effects of sampling schemes in systems biology applications

Cited in

(8)

• Estimating decay curves of neutralizing antibodies to SARS-CoV-2 infection
• Determination of significant immunological timescales from mRNA-LNP-based vaccines in humans
• A mathematical model of protein subunits COVID-19 vaccines
• A mathematical model for the within-host (re)infection dynamics of SARS-CoV-2
• Multiscale modeling approach to assess the impact of antibiotic treatment for COVID-19 on MRSA transmission and alternative immunotherapy treatment options
• Studies on the interaction mechanism between the mRNA vaccine against SARS-CoV-2 and the immune system
• Understanding antibody magnitude and durability following vaccination against SARS-CoV-2
• Prevalence estimation methods for time-dependent antibody kinetics of infected and vaccinated individuals: a Markov chain approach

Describes a project that uses

Uses Software

• Optimization Toolbox
• Matlab
• MCMCSTAT
• Monolix

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