A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: development of an integrated mathematical model and computational experiments

DOI10.1016/J.JTBI.2022.111326MaRDI QIDQ2109268zbMATH OpenOpenAlexWikidataFDO

Authors Raheel Khan, Don Kulasiri, Sandhya Samarasinghe

Publication date 20 December 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111326

zbMATH Keywords

CaMKII-NMDAR complexF-actinlate-long term potentiationmemory allocationsynaptic tagging

Mathematics Subject Classification ID

Memory and learning in psychology (91E40) Neural networks for/in biological studies, artificial life and related topics (92B20) Biochemistry, molecular biology (92C40)

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Cites work

• Modelling bidirectional modulations in synaptic plasticity: a biochemical pathway model to understand the emergence of long term potentiation (LTP) and long term depression (LTD)
• Simulations suggest pharmacological methods for rescuing long-term potentiation

Cited in

(4)

• A computational model of dopaminergic modulation of hippocampal schaffer collateral-CA1 long-term plasticity
• Modelling the dynamics of CaMKII-NMDAR complex related to memory formation in synapses: the possible roles of threonine 286 autophosphorylation of CaMKII in long term potentiation
• Modelling bidirectional modulations in synaptic plasticity: a biochemical pathway model to understand the emergence of long term potentiation (LTP) and long term depression (LTD)
• Hysteresis and bistability in synaptic transmission modeled as a chain of biochemical reactions with a positive feedback

Describes a project that uses

Uses Software

• BioNetGen

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