Two-phase model of compressive stress induced on a surrounding hyperelastic medium by an expanding tumour

DOI10.1007/S00285-022-01851-YMaRDI QIDQ2111083zbMATH OpenOpenAlexFDO

Authors Gopikrishnan C. Remesan, Jennifer A. Flegg, H. M. Byrne

Publication date 23 December 2022

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2206.04989

zbMATH Keywords

strain energy densityhyperelasticitymechanical stresstwo-phase mixture modeltumour growth and elimination

Mathematics Subject Classification ID

PDEs in connection with fluid mechanics (35Q35) PDEs in connection with mechanics of deformable solids (35Q74) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite volume methods for initial value and initial-boundary value problems involving PDEs (65M08) Nonlinear elasticity (74B20) Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37) Numerical methods for initial value problems involving ordinary differential equations (65L05) Liquid-liquid two component flows (76T06)

Abstract: emph{In vitro} experiments in which tumour cells are seeded in a gelatinous medium, or hydrogel, show how mechanical interactions between tumour cells and the tissue in which they are embedded, together with local levels of an externally-supplied, diffusible nutrient (e.g., oxygen), affect the tumour's growth dynamics. In this article, we present a mathematical model that describes these emph{in vitro} experiments. We use the model to understand how tumour growth generates mechanical deformations in the hydrogel and how these deformations in turn influence the tumour's growth. The hydrogel is viewed as a nonlinear hyperelastic material and the tumour is modelled as a two-phase mixture, comprising a viscous tumour cell phase and an isotropic, inviscid interstitial fluid phase. Using a combination of numerical and analytical techniques, we show how the tumour's growth dynamics change as the mechanical properties of the hydrogel vary. When the hydrogel is soft, nutrient availability dominates the dynamics: the tumour evolves to a large equilibrium configuration where the proliferation rate of nutrient-rich cells on the tumour boundary balances the death rate of nutrient-starved cells in the central, necrotic core. As the hydrogel stiffness increases, mechanical resistance to growth increases and the tumour's equilibrium size decreases. Indeed, for small tumours embedded in stiff hydrogels, the inhibitory force experienced by the tumour cells may be so large that the tumour is eliminated. Analysis of the model identifies parameter regimes in which the presence of the hydrogel drives tumour elimination.

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Cited in

(4)

• The influence of growth-induced stress from the surrounding medium on the development of multicell spheroids
• A mathematical model for cell-induced gel compaction in vitro
• A poroelasticity theory approach to study the mechanisms leading to elevated interstitial fluid pressure in solid tumours
• Buckling condensation in constrained growth

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