The spatio-temporal dynamics of interacting genetic incompatibilities. Part I: the case of stacked underdominant clines

DOI10.1007/S00285-022-01722-6MaRDI QIDQ2113520zbMATH OpenOpenAlexWikidataFDO

Authors Matthieu Alfaro, Quentin Griette, Denis Roze, Benoît Sarels

Publication date 14 March 2022

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2101.06008

zbMATH Keywords

traveling waveperturbation analysisstanding waveunderdominancequasi-linkage equilibriumgenetic incompatibilities

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Perturbations in context of PDEs (35B20) Traveling wave solutions (35C07)

Abstract: We explore the interaction between two genetic incompatibilities (underdominant loci in diploid organisms) in a population occupying a one-dimensional space. We derive a system of partial differential equations describing the dynamics of allele frequencies and linkage disequilibrium between the two loci, and use a quasi-linkage equilibrium approximation in order to reduce the number of variables. We investigate the solutions of this system and demonstrate the existence of a solution in which the two clines in allele frequency remain stacked together. In the case of asymmetric incompatibilities (i.e. when one homozygote is favored over the other at each locus), these stacked clines propagate in the form of a traveling wave. We obtain an approximation for the speed of this wave which, in particular, is decreased by recombination between the two loci but is always larger than the speed of "one cline alone".

Recommendations

• Two-locus clines maintained by diffusion and recombination in a heterogeneous environment
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Cites work

• scientific article; zbMATH DE number 3933857 (Why is no real title available?)
• Elliptic partial differential equations. Volume 1: Fredholm theory of elliptic problems in unbounded domains
• On the stability of waves of nonlinear parabolic systems
• Topological degree for elliptic operators in unbounded cylinders
• Travelling waves for integro-differential equations in population dynamics

Cited in

(2)

• With whom is the gene in conflict in offspring production?: Synthesis of the theories of intragenomic and parent-offspring conflict
• The wave speed of intergradation zone in two-species lattice Müllerian mimicry model

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