The spatio-temporal dynamics of interacting genetic incompatibilities. Part I: the case of stacked underdominant clines

DOI10.1007/S00285-022-01722-6zbMATH Open1486.92123arXiv2101.06008OpenAlexW3148141674WikidataQ113905400 ScholiaQ113905400MaRDI QIDQ2113520FDOQ2113520

Quentin Griette, Denis Roze, Benoît Sarels, Matthieu Alfaro

Publication date: 14 March 2022

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: We explore the interaction between two genetic incompatibilities (underdominant loci in diploid organisms) in a population occupying a one-dimensional space. We derive a system of partial differential equations describing the dynamics of allele frequencies and linkage disequilibrium between the two loci, and use a quasi-linkage equilibrium approximation in order to reduce the number of variables. We investigate the solutions of this system and demonstrate the existence of a solution in which the two clines in allele frequency remain stacked together. In the case of asymmetric incompatibilities (i.e. when one homozygote is favored over the other at each locus), these stacked clines propagate in the form of a traveling wave. We obtain an approximation for the speed of this wave which, in particular, is decreased by recombination between the two loci but is always larger than the speed of "one cline alone".

Full work available at URL: https://arxiv.org/abs/2101.06008

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zbMATH Keywords

traveling waveperturbation analysisstanding waveunderdominancequasi-linkage equilibriumgenetic incompatibilities

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Perturbations in context of PDEs (35B20) Traveling wave solutions (35C07)

Cites Work

• Travelling waves for integro-differential equations in population dynamics
• On the stability of waves of nonlinear parabolic systems
• Title not available (Why is that?)
• Elliptic partial differential equations. Volume 1: Fredholm theory of elliptic problems in unbounded domains
• Topological degree for elliptic operators in unbounded cylinders

Cited In (1)

• With whom is the gene in conflict in offspring production?: Synthesis of the theories of intragenomic and parent-offspring conflict

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