A Fokker-Planck feedback control framework for optimal personalized therapies in colon cancer-induced angiogenesis

DOI10.1007/S00285-022-01725-3MaRDI QIDQ2113523zbMATHOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 14 March 2022

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2109.00166

zbMATH Keywords

Weibull distributionchemotherapynon-linear conjugate gradientanti-angiogenic drugsFokker-Planck optimization

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) Statistical sampling theory and related topics (62D99) Fokker-Planck equations (35Q84) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Inverse problems for PDEs (35R30) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Computational methods for problems pertaining to biology (92-08) Physiological flow (92C35) Cell biology (92C37) Feedback control (93B52) PDE constrained optimization (numerical aspects) (49M41)

Abstract: In this paper, a new framework for obtaining personalized optimal treatment strategies in colon cancer-induced angiogenesis is presented. The dynamics of colon cancer is given by a It'o stochastic process, which helps in modeling the randomness present in the system. The stochastic dynamics is then represented by the Fokker-Planck (FP) partial differential equation (PDE) that governs the evolution of the associated probability density function. The optimal therapies are obtained using a three step procedure. First, a finite dimensional FP-constrained optimization problem is formulated that takes input individual noisy patient data, and is solved to obtain the unknown parameters corresponding to the individual tumor characteristics. Next, a sensitivity analysis of the optimal parameter set is used to determine the parameters to be controlled, thus, helping in assessing the types of treatment therapies. Finally, a feedback FP control problem is solved to determine the optimal combination therapies. Numerical results with the combination drug, comprising of Bevacizumab and Capecitabine, demonstrate the efficiency of the proposed framework.

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• A robust optimal control framework for controlling aberrant RTK signaling pathways in esophageal cancer
• On the parameter estimation of Box-Cox transformation cure model

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