Altered neuronal excitability in a Hodgkin-Huxley model incorporating channelopathies of the delayed rectifier Potassium channel

DOI10.1007/S10827-020-00766-1MaRDI QIDQ2137286zbMATH OpenOpenAlexWikidataFDO

Authors Omar A. Hafez, Allan Gottschalk

Publication date 16 May 2022

Published in Journal of Computational Neuroscience (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10827-020-00766-1

zbMATH Keywords

Hopf bifurcationnonlinear dynamical systemHodgkin-Huxley modelneuronal excitabilityepisodic ataxia type 1Kv1.1 channelopathy

Mathematics Subject Classification ID

Neural biology (92C20) Pathology, pathophysiology (92C32)

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Cites work

• scientific article; zbMATH DE number 3757349 (Why is no real title available?)
• Bifurcation of the Hodgkin and Huxley equations: A new twist
• Chaos in the Hodgkin--Huxley Model
• Computing Hopf Bifurcations. II: Three Examples From Neurophysiology
• Hopf bifurcations in multiple-parameter space of the Hodgkin-Huxley equations. I: Global organization of bistable periodic solutions
• Local birth of homoclinic chaos
• NEURAL EXCITABILITY, SPIKING AND BURSTING
• New features of the software M<scp>at</scp>C<scp>ont</scp>for bifurcation analysis of dynamical systems
• Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
• Numerical calculation of stable and unstable periodic solutions to the Hodgkin-Huxley equations
• The entwined wiggling of homoclinic curves emerging from saddle-node/Hopf instabilities
• Two-parameters Hopf bifurcation in the Hodgkin-Huxley model

Cited in

(3)

• Slowly-inactivating potassium conductances in compartmental interneuron models
• The potassium A-current, low firing rates and rebound excitation in Hodgkin-Huxley models
• Functional role of the activity of ATP-sensitive potassium channels in electrical behavior of hippocampal neurons: experimental and theoretical studies

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Uses Software

• MATCONT

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