Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging

DOI10.1007/S10827-020-00774-1MaRDI QIDQ2137322zbMATH OpenOpenAlexFDO

Authors Lorenzo Chicchi, Gloria Cecchini, Ihusan Adam, Giuseppe de Vito, Roberto Livi, Francesco Saverio Pavone, Ludovico Silvestri, Lapo Turrini, Francesco Vanzi, Duccio Fanelli

Publication date 16 May 2022

Published in Journal of Computational Neuroscience (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2007.04370

zbMATH Keywords

heterogeneous mean field approximationleak integrate and firenetwork reconstructionneurosciencezebrafish larva

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: An inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas.

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Cites work

• Dynamical Processes on Complex Networks

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