Perivascular pumping in the mouse brain: improved boundary conditions reconcile theory, simulation, and experiment

DOI10.1016/J.JTBI.2022.111103MaRDI QIDQ2137455zbMATHOpenAlexFDO

Authors Antonio Ladrón-de-Guevara, Jessica K. Shang, Maiken Nedergaard, Douglas H. Kelley

Publication date 16 May 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111103

zbMATH Keywords

cerebrospinal fluidcompliancehydraulic resistancebrainperivascular pumpingglymphatic system

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20) Physiological flow (92C35)

Recommendations

• Cerebrospinal fluid flow driven by arterial pulsations in axisymmetric perivascular spaces: analogy with Taylor's swimming sheet
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Cites work

• Automated tuning for parameter identification and uncertainty quantification in multi-scale coronary simulations
• Fluid mechanics in the perivascular space
• Mechanisms to explain the reverse perivascular transport of solutes out of the brain
• Outflow boundary conditions for three-dimensional finite element modeling of blood flow and pressure in arteries

Cited in

(8)

• On boundary permeation through the walls of blocked cerebral capillaries: a non-linear model
• On the bulk motion of the cerebrospinal fluid in the spinal canal
• Cerebrospinal fluid flow driven by arterial pulsations in axisymmetric perivascular spaces: analogy with Taylor's swimming sheet
• Fluid mechanics in the perivascular space
• Directional flow in perivascular networks: mixed finite elements for reduced-dimensional models on graphs
• Pulsations with reflected boundary waves: a hydrodynamic reverse transport mechanism for perivascular drainage in the brain
• Mechanisms to explain the reverse perivascular transport of solutes out of the brain
• Implications of transvascular fluid exchange in nonlinear, biphasic analyses of flow-controlled infusion in brain

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