GMEPS: a fast and efficient likelihood approach for genome-wide mediation analysis under extreme phenotype sequencing

DOI10.1515/SAGMB-2021-0071zbMath1494.92068OpenAlexW4221129279MaRDI QIDQ2162487

Motomi Mori, Kumar Srivastava, Yun Li, Janaka S. S. Liyanage, Jeremie H. Estepp, Guolian Kang

Publication date: 8 August 2022

Published in: Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/sagmb-2021-0071

zbMATH Keywords

genome-wide association studiesmediation analysisextreme phenotype sequencingmediation effectnext generation sequencing studies

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20) Genetics and epigenetics (92D10)

Uses Software

• mediation
• SEAS5

Cites Work

• Identification, inference and sensitivity analysis for causal mediation effects
• Mediation Analysis with Multiple Mediators
• Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies
• A Multiple-Testing Procedure for High-Dimensional Mediation Hypotheses

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