Upscaling between an agent-based model (smoothed particle approach) and a continuum-based model for skin contractions

DOI10.1007/S00285-022-01770-YzbMATH Open1498.92063arXiv2105.09110OpenAlexW3162175888WikidataQ113905350 ScholiaQ113905350MaRDI QIDQ2170643FDOQ2170643

Authors: Q. Peng, Fred J. Vermolen 

Publication date: 6 September 2022

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Skin contraction is an important biophysical process that takes place during and after the recovery of deep tissue injury. This process is mainly caused by fibroblasts (skin cells) and myofibroblasts (differentiated fibroblasts) that exert pulling forces on the surrounding extracellular matrix (ECM). Modelling is done in multiple scales: agent-based modelling on the microscale and continuum-based modelling on the macroscale. In this manuscript, we present some results from our study of the connection between these scales. For the one-dimensional case, we managed to rigorously establish the link between the two modelling approaches for both closed-form solutions and finite-element approximations. For the multidimensional case, we computationally evidence the connection between the agent-based and continuum-based modelling approaches.

Full work available at URL: https://arxiv.org/abs/2105.09110

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zbMATH Keywords

mechanicsagent-based modellingfinite-element methodstraction forcescontinuum-based modellingsmoothed particle approach

Mathematics Subject Classification ID

Biomechanics (92C10) Pathology, pathophysiology (92C32)

Cites Work

• Computational Methods for Fluid Dynamics
• Finite Elements
• Point forces in elasticity equation and their alternatives in multi dimensions
• A Multivariate Tchebycheff Inequality
• Title not available (Why is that?)
• Numerical methods to compute stresses and displacements from cellular forces: application to the contraction of tissue
• Point Forces and Their Alternatives in Cell-Based Models for Skin Contraction

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