Intercellular communication via intracellular calcium oscillations

DOI10.1006/JTBI.2003.3201zbMATH Open1464.92084arXivphysics/0111137OpenAlexW2145721286WikidataQ48597501 ScholiaQ48597501MaRDI QIDQ2177142FDOQ2177142

Authors: J. D. Gunton, Maria E. Gracheva 

Publication date: 6 May 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: In this letter we present the results of a simple model for intercellular communication via calcium oscillations, motivated in part by a recent experimental study. The model describes two cells (a "donor" and "sensor") whose intracellular dynamics involve a calcium-induced, calcium release process. The cells are coupled by assuming that the the input of the sensor cell is proportional to the output of the donor cell. As one varies the frequency of calcium oscillations of the donor cell, the sensor cell passes through a sequence of N:M phase locked regimes and exhibits a "Devil's staircase" behavior. Such a phase locked response has been seen experimentally in pulsatile stimulation of single cells. We also study a stochastic version of the coupled two cell model. We find that phase locking holds for realistic choices for the cell volume.

Full work available at URL: https://arxiv.org/abs/physics/0111137

Recommendations

• A bifurcation analysis of two coupled calcium oscillators
• \([\operatorname{Ca}^{2+}]\) oscillations in a model of energy-dependent \(\text{Ca}^{2+}\) uptake by the endoplasmic reticulum
• Modelling oscillations and waves of cytosolic calcium
• Cellular calcium oscillations: from bifurcation analysis to experiment
• scientific article; zbMATH DE number 5032042

Mathematics Subject Classification ID

Cell biology (92C37)

Cites Work

• Title not available (Why is that?)
• Practical bifurcation and stability analysis: from equilibrium to chaos.

Cited In (6)

• Emergent properties of electrically coupled smooth muscle cells
• Oscillating two-dimensional Ca²⁺ waves in cell networks with bidirectional paracrine signaling
• Electromagnetic field absorption in stochastic cellular systems: Enhanced signal detection in ion channels and calcium oscillators
• Calcium oscillations in astrocytes. Part 2. Dynamics of interacting calcium oscillators
• Long-range intercellular \(Ca^{2+}\) wave patterns
• Localized modulated wave solutions in diffusive glucose-insulin systems

This page was built for publication: Intercellular communication via intracellular calcium oscillations

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2177142)