Intercellular communication via intracellular calcium oscillations

DOI10.1006/JTBI.2003.3201MaRDI QIDQ2177142zbMATH OpenOpenAlexWikidataFDO

Authors J. D. Gunton, Maria E. Gracheva

Publication date 6 May 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/physics/0111137

Mathematics Subject Classification ID

Cell biology (92C37)

Abstract: In this letter we present the results of a simple model for intercellular communication via calcium oscillations, motivated in part by a recent experimental study. The model describes two cells (a "donor" and "sensor") whose intracellular dynamics involve a calcium-induced, calcium release process. The cells are coupled by assuming that the the input of the sensor cell is proportional to the output of the donor cell. As one varies the frequency of calcium oscillations of the donor cell, the sensor cell passes through a sequence of N:M phase locked regimes and exhibits a "Devil's staircase" behavior. Such a phase locked response has been seen experimentally in pulsatile stimulation of single cells. We also study a stochastic version of the coupled two cell model. We find that phase locking holds for realistic choices for the cell volume.

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Cites work

• scientific article; zbMATH DE number 819507 (Why is no real title available?)
• Practical bifurcation and stability analysis: from equilibrium to chaos.

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