Reconstructing metabolic flux vectors from extreme pathways: defining the -spectrum

DOI10.1016/S0022-5193(03)00168-1MaRDI QIDQ2177359zbMATH OpenOpenAlexWikidataFDO

Authors Sharon J. Wiback, Radhakrishnan Mahadevan, Bernhard Ø. Palsson

Publication date 6 May 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/s0022-5193(03)00168-1

zbMATH Keywords

elementary flux modehuman red blood cellextreme pathway analysis\textit{in silico} modelpathway-based perspective

Mathematics Subject Classification ID

Systems biology, networks (92C42) Mixed integer programming (90C11) Cell biology (92C37)

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Cites work

• Constraints-based models: regulation of gene expression reduces the steady-state solution space
• Model building in mathematical programming.

Cited in

(12)

• Network-based analysis of metabolic regulation in the human red blood cell
• Multiscale flux-based modeling of biofilm communities
• Stoichiometric and constraint-based analysis of biochemical reaction networks
• A new constraint-based description of the steady-state flux cone of metabolic networks
• An interval approach for dealing with flux distributions and elementary modes activity patterns
• Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space
• Constraints-based models: regulation of gene expression reduces the steady-state solution space
• Metabolic network analysis of perfused livers under fed and fasted states: incorporating thermodynamic and futile-cycle-associated regulatory constraints
• Bayesian flux balance analysis applied to a skeletal muscle metabolic model
• Finding MEMo: minimum sets of elementary flux modes
• Pathway analysis of liver metabolism under stressed condition
• A Markov constraint to uniquely identify elementary flux mode weights in unimolecular metabolic networks

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