Simple step-stress models with a cure fraction

DOI10.1214/18-BJPS409zbMATH Open1451.62109arXiv1807.01137OpenAlexW3004731779MaRDI QIDQ2180252FDOQ2180252

Authors: Nandini Kannan, Debasis Kundu 

Publication date: 13 May 2020

Published in: Brazilian Journal of Probability and Statistics (Search for Journal in Brave)

Abstract: In this article, we consider models for time-to-event data obtained from experiments in which stress levels are altered at intermediate stages during the observation period. These experiments, known as step-stress tests, belong to the larger class of accelerated tests used extensively in the reliability literature. The analysis of data from step-stress tests largely relies on the popular cumulative exposure model. However, despite its simple form, the utility of the model is limited, as it is assumed that the hazard function of the underlying distribution is discontinuous at the points at which the stress levels are changed, which may not be very reasonable. Due to this deficiency, Kannan et al. cite{KKNT:2010} introduced the cumulative risk model, where the hazard function is continuous. In this paper we propose a class of parametric models based on the cumulative risk model assuming the underlying population contains long-term survivors or `cured' fraction. An EM algorithm to compute the maximum likelihood estimators of the unknown parameters is proposed. This research is motivated by a study on altitude decompression sickness. The performance of different parametric models will be evaluated using data from this study.

Full work available at URL: https://arxiv.org/abs/1807.01137

Recommendations

• Inference in step-stress models based on failure rates
• A synthesis of exact inferential results for exponential step-stress models and associated optimal accelerated life-tests
• Exact inference for a simple step-stress model with competing risks for failure from exponential distribution under type-II censoring
• Order restricted Bayesian inference for exponential simple step-stress model
• Inference for a simple step-stress model with competing risks for failure from the exponential distribution under time constraint
• Analysis of progressive Type‐II censoring in presence of competing risk data under step stress modeling
• Step stress model with threshold parameter

zbMATH Keywords

EM algorithmmaximum likelihood estimationcumulative exposure modelcured fractionstep-stress tests

Mathematics Subject Classification ID

Point estimation (62F10) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential estimation (62L12)

Cites Work

• Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests Under Nonstandard Conditions
• A New Bayesian Model for Survival Data with a Surviving Fraction
• A Proportional Hazards Model Taking Account of Long-Term Survivors
• Survival analysis with long-term survivors
• Generalized exponential distributions
• Title not available (Why is that?)
• Accelerated Testing
• Statistical inference for a step-stress partially-accelerated life test model with an adaptive type-I progressively hybrid censored data from Weibull distribution
• A tampered failure rate model for step-stress accelerated life test
• A synthesis of exact inferential results for exponential step-stress models and associated optimal accelerated life-tests
• Accelerated Life Testing - Step-Stress Models and Data Analyses
• Optimum simple step-stress accelerated life tests with censoring
• Asymptotic Results for Exponential Mixture Models with Long-Term Survivors
• The generalized exponential cure rate model with covariates
• Modeling the presence of immunes by using the exponentiated-Weibull model
• Bayesian analysis for step-stress accelerated life testing using Weibull proportional hazard model
• Inference in step-stress models based on failure rates
• A Parametric Model for Studying Organism Fitness Using Step-Stress Experiments

Cited In (5)

• Order restricted inference for a multiple step-stress model with long-term survivors for a general family of distributions
• Exact inference of a simple step-stress model with hybrid type-II stress changing time
• Step-stress model using logistic regression model and its application in medicine
• Cure rate-based step-stress model
• A Parametric Model for Studying Organism Fitness Using Step-Stress Experiments

This page was built for publication: Simple step-stress models with a cure fraction

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2180252)