Modeling stripe formation on growing zebrafish tailfins

DOI10.1007/S11538-020-00731-0MaRDI QIDQ2183173zbMATH OpenOpenAlexWikidataFDO

Authors Yanyan Li

Publication date 26 May 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1911.03758

zbMATH Keywords

agent-based modelgrowing domainpattern formationself-organizationtailfinzebrafish

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

Abstract: As zebrafish develop, black and gold stripes form across their skin due to the interactions of brightly colored pigment cells. These characteristic patterns emerge on the growing fish body, as well as on the anal and caudal fins. While wild-type stripes form parallel to a horizontal marker on the body, patterns on the tailfin gradually extend distally outward. Interestingly, several mutations lead to altered body patterns without affecting fin stripes. Through an exploratory modeling approach, our goal is to help better understand these differences between body and fin patterns. By adapting a prior agent-based model of cell interactions on the fish body, we present an in silico study of stripe development on tailfins. Our main result is a demonstration that two cell types can produce stripes on the caudal fin. We highlight several ways that bone rays, growth, and the body-fin interface may be involved in patterning, and we raise questions for future work related to pattern robustness.

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Cites work

• A nonlocal model for contact attraction and repulsion in heterogeneous cell populations
• A theory of biological pattern formation
• How does cellular contact affect differentiation mediated pattern formation?
• The chemical basis of morphogenesis

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(12)

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• Nonlocal Cross-Interaction Systems on Graphs: Nonquadratic Finslerian Structure and Nonlinear Mobilities
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