Modeling stripe formation on growing zebrafish tailfins

DOI10.1007/S11538-020-00731-0zbMATH Open1443.92056arXiv1911.03758OpenAlexW3023811636WikidataQ94476777 ScholiaQ94476777MaRDI QIDQ2183173FDOQ2183173

Authors: Yanyan Li 

Publication date: 26 May 2020

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: As zebrafish develop, black and gold stripes form across their skin due to the interactions of brightly colored pigment cells. These characteristic patterns emerge on the growing fish body, as well as on the anal and caudal fins. While wild-type stripes form parallel to a horizontal marker on the body, patterns on the tailfin gradually extend distally outward. Interestingly, several mutations lead to altered body patterns without affecting fin stripes. Through an exploratory modeling approach, our goal is to help better understand these differences between body and fin patterns. By adapting a prior agent-based model of cell interactions on the fish body, we present an in silico study of stripe development on tailfins. Our main result is a demonstration that two cell types can produce stripes on the caudal fin. We highlight several ways that bone rays, growth, and the body-fin interface may be involved in patterning, and we raise questions for future work related to pattern robustness.

Full work available at URL: https://arxiv.org/abs/1911.03758

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zbMATH Keywords

self-organizationpattern formationgrowing domainagent-based modelzebrafishtailfin

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

Cites Work

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Cited In (9)

• Methodology for Reconstructing Early Zebrafish Development From In Vivo Multiphoton Microscopy
• A local continuum model of cell-cell adhesion
• Modeling factors that regulate cell cooperativity in the zebrafish posterior lateral line primordium
• Nonlocal Cross-Interaction Systems on Graphs: Nonquadratic Finslerian Structure and Nonlinear Mobilities
• Nonlocal cross-interaction systems on graphs: energy landscape and dynamics
• Quantifying Different Modeling Frameworks Using Topological Data Analysis: A Case Study with Zebrafish Patterns
• A hybrid integro-differential model for the early development of the zebrafish posterior lateral line
• Numerical simulation of the zebra pattern formation on a three-dimensional model
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