Optimizing within-host viral fitness: infected cell lifespan and virion production rate
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Publication:2189284
DOI10.1016/J.JTBI.2004.04.015zbMATH Open1440.92026OpenAlexW2170271908WikidataQ80221968 ScholiaQ80221968MaRDI QIDQ2189284FDOQ2189284
Authors: Michael A. Gilchrist, Daniel Coombs, Alan S. Perelson 
Publication date: 15 June 2020
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.jtbi.2004.04.015
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- Optimal viral production
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- An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
- A model for treatment strategy in the chemotherapy of AIDS
- Drug concentration heterogeneity facilitates the evolution of drug resistance
- Analysis of a model for the pathogenesis of AIDS
Cited In (41)
- Dynamics of evolutionary competition between budding and lytic viral release strategies
- Optimal viral production
- Global dynamics of an age-structured in-host viral infection model with humoral immunity
- Mathematical modeling of HIV-1 infection and drug therapy
- Trade-offs in resource allocation in the intracellular life-cycle of hepatitis C virus
- The impact of host-cell dynamics on the fixation probability for lytic viruses
- Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens
- Modeling the within-host co-infection of influenza a virus and pneumococcus
- Virulence of a virus: how it depends on growth rate, effectors, memory cells, and immune escape
- The function of temporally ordered viral gene expression in the intracellular replication of herpes simplex virus type 1 (HSV-1)
- Evolution of viral life-cycle in response to cytotoxic T lymphocyte-mediated immunity
- Optimal treatment in a multi-strain within-host model of HIV with age structure
- Global properties for an age-structured within-host model with Crowley-Martin functional response
- An HIV infection model based on a vectored immunoprophylaxis experiment
- Optimal growth schedule of pathogens within a host: Switching between lytic and latent cycles
- Linking immunological and epidemiological dynamics of HIV: the case of super-infection
- Global stability of a viral infection model with defectively infected cells and latent age
- Rich dynamics of a simple delay host-pathogen model of cell-to-cell infection for plant virus
- A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins
- Modeling within-host viral dynamics: the role of CTL immune responses in the evolution of drug resistance
- Dynamics of a diffusive age-structured HBV model with saturating incidence
- Immune response in virus model structured by cell infection-age
- A multi-strain virus model with infected cell age structure: application to HIV
- Global dynamics for a class of age-infection HIV models with nonlinear infection rate
- The role of pathogen shedding in linking within- and between-host pathogen dynamics
- Time periodic reaction-diffusion equations for modeling 2-LTR dynamics in HIV-infected patients
- Evolution of virulence: interdependence, constraints, and selection using nested models
- Long-time behavior of a PDE replicator equation for multilevel selection in group-structured populations
- On the relative fitness of early and late stage Simian immunodeficiency virus isolates
- Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility
- The replicator dynamics for multilevel selection in evolutionary games
- Assortment and reciprocity mechanisms for promotion of cooperation in a model of multilevel selection
- Modeling within-host evolution of HIV: mutation, competition and strain replacement
- A note on the global properties of an age-structured viral dynamic model with multiple target cell populations
- Local and global stabilities of a viral dynamics model with infection-age and immune response
- Two optimal mutation rates in obligate pathogens subject to deleterious mutation
- Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus
- Analysis of multilevel replicator dynamics for general two-strategy social dilemma
- Global dynamics for an age-structured HIV virus infection model with cellular infection and antiretroviral therapy
- An age-structured model of HIV latent infection with two transmission routes: analysis and optimal control
- Immune response and within-host viral evolution: immune response can accelerate evolution
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