A graph model for the evolution of specificity in humoral immunity

DOI10.1016/J.JTBI.2004.04.005MaRDI QIDQ2189292zbMATH OpenOpenAlexWikidataFDO

Authors Luis E. Flores, Eduardo J. Aguilar, Valmir C. Barbosa, Luís Alfredo V. de Carvalho

Publication date 15 June 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0310030

zbMATH Keywords

functional networkidiotypic networkimmune-system specificity

Mathematics Subject Classification ID

Computational methods for problems pertaining to biology (92-08) Physiology (general) (92C30) Systems biology, networks (92C42)

Abstract: The immune system protects the body against health-threatening entities, known as antigens, through very complex interactions involving the antigens and the system's own entities. One remarkable feature resulting from such interactions is the immune system's ability to improve its capability to fight antigens commonly found in the individual's environment. This adaptation process is called the evolution of specificity. In this paper, we introduce a new mathematical model for the evolution of specificity in humoral immunity, based on Jerne's functional, or idiotypic, network. The evolution of specificity is modeled as the dynamic updating of connection weights in a graph whose nodes are related to the network's idiotypes. At the core of this weight-updating mechanism are the increase in specificity caused by clonal selection and the decrease in specificity due to the insertion of uncorrelated idiotypes by the bone marrow. As we demonstrate through numerous computer experiments, for appropriate choices of parameters the new model correctly reproduces, in qualitative terms, several immune functions.

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Cited in

(7)

• Random walks on binary strings applied to the somatic hypermutation of B-cells
• On the dynamics of matrix models for immune clonal networks
• Model for comparative analysis of antigen receptor repertoires
• Quasispecies dynamics on a network of interacting genotypes and idiotypes: formulation of the model
• Quasispecies dynamics on a network of interacting genotypes and idiotypes: applications to autoimmunity and immunodeficiency
• Adaptation of learning antigens by gene recombination in the immune system
• LOCALIZATION AND GLASSY DYNAMICS IN THE IMMUNE SYSTEM

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