Active transport: a kinetic description based on thermodynamic grounds

DOI10.1016/J.JTBI.2004.11.001MaRDI QIDQ2193097zbMATH OpenOpenAlexWikidataFDO

Authors Signe Kjelstrup, J. M. Rubi, D. Bedeaux

Publication date 24 August 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/cond-mat/0412493

zbMATH Keywords

active transportion channelskineticsmolecular motorsnonequilibrium thermodynamics

Mathematics Subject Classification ID

Irreversible thermodynamics, including Onsager-Machlup theory (82C35) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: We show that active transport processes in biological systems can be understood through a local equilibrium description formulated at the mesoscale, the scale to describe stochastic processes. This new approach uses the method established by nonequilibrium thermodynamics to account for the irreversible processes occurring at this scale and provides nonlinear kinetic equations for the rates in terms of the driving forces. The results show that the application domain of nonequilibrium thermodynamics method to biological systems goes beyond the linear domain. A model for transport of Ca${}^{2+}$ by the Ca${}^{2+}$-ATPase, coupled to the hydrolysis of adenosine-triphosphate is analyzed in detail showing that it depends on the reaction Gibbs energy in a non-linear way. Our results unify thermodynamic and kinetic descriptions, thereby opening new perspectives in the study of different transport phenomena in biological systems.

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Cites work

• Brownian motion in a field of force and the diffusion model of chemical reactions
• scientific article; zbMATH DE number 3187569 (Why is no real title available?)

Cited in

(15)

• An asymptotic study to explain the role of active transport in models with countercurrent exchangers
• Nonlinear thermodynamics of biological signal transduction for predicting conservation of entropy production rate
• Model of active transport of ions in biomembranes based on ATP-dependent change of height of diffusion barriers to ions
• A thermodynamic framework for modelling membrane transporters
• Response of a thermodynamic system subject to stochastic thermal perturbations
• Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate
• Energy transduction in biological systems: A mesoscopic non-equilibrium thermodynamics perspective
• Nonequilibrium thermodynamics modeling of coupled biochemical cycles in living cells
• Active transport improves the precision of linear long distance molecular signalling
• Non-equilibrium thermodynamics of light absorption
• Mesoscopic non-equilibrium thermodynamics and biological systems
• scientific article; zbMATH DE number 5262808 (Why is no real title available?)
• Quantifying the flux as the driving force for nonequilibrium dynamics and thermodynamics in non-Michaelis-Menten enzyme kinetics
• Nonequilibrium steady state of biochemical cycle kinetics under non-isothermal conditions
• Active ion transport as the basis for water movement in plants

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