Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses

DOI10.1016/J.JTBI.2005.11.010zbMATH Open1447.92086OpenAlexW2082494258WikidataQ51956212 ScholiaQ51956212MaRDI QIDQ2199169FDOQ2199169

Authors: Nigel J. Burroughs, Bruno Miguel Paz Mendes de Oliveira, Alberto Pinto 

Publication date: 16 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://repositorio.inesctec.pt/handle/123456789/2867

Recommendations

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zbMATH Keywords

immunologygrowth modelcytokinesODE modelsecretion inhibitionquorum thresholdtregs

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Pathology, pathophysiology (92C32)

Cites Work

• Perturbation theory analysis of competition in a heterogeneous population
• Tolerance and immunity in a mathematical model of T-cell mediated suppression

Cited In (25)

• Modelling the suppression of autoimmunity after pathogen infection
• Mathematical methods and modeling of biophysical phenomena
• Sensibility of the quorum growth thresholds controlling local immune responses
• Autoimmunity arising from bystander proliferation of T cells in an immune response model
• Immune response dynamics
• A mathematical model of pancreatic cancer with two kinds of treatments
• A fit of CD4\(^+\) T cell immune response to an infection by lymphocytic choriomeningitis virus
• A transcritical bifurcation in an immune response model
• Advantage of having regulatory T cells requires localized suppression of immune reactions
• Lifelong dynamics of human CD4\(^+\)CD25\(^+\) regulatory T cells: insights from \textit{in vivo} data and mathematical modeling
• A mathematical perspective on CD4\(^{+}\) T cell quorum-sensing
• Emergent group dynamics governed by regulatory cells produce a robust primary T cell response
• Optimal T cell cross-reactivity and the role of regulatory T cells
• Functional switching and stability of regulatory T cells
• Dynamics and biological thresholds
• Bifurcations and multistability in a model of cytokine-mediated autoimmunity
• Optimal number of regulatory T cells
• Time-delayed model of autoimmune dynamics
• Comparing antigen-independent mechanisms of T cell regulation
• Modeling regulation mechanisms in the immune system
• Mathematical modeling of allergy and specific immunotherapy: Th1-Th2-Treg interactions
• Stochastic dynamics in a time-delayed model for autoimmunity
• The role of the T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model
• Immune response model fitting to \(\mathrm{CD4^+}\) \(\mathrm{T}\) cell data in \textit{lymphocytic choriomeningitis virus} LCMV infection
• Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response

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