Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses

DOI10.1016/J.JTBI.2005.11.010MaRDI QIDQ2199169zbMATH OpenOpenAlexWikidataFDO

Authors Nigel J. Burroughs, Bruno Miguel Paz Mendes de Oliveira, Alberto Pinto

Publication date 16 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://repositorio.inesctec.pt/handle/123456789/2867

zbMATH Keywords

immunologygrowth modelcytokinesODE modelsecretion inhibitionquorum thresholdtregs

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Pathology, pathophysiology (92C32)

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Cites work

• Perturbation theory analysis of competition in a heterogeneous population
• Tolerance and immunity in a mathematical model of T-cell mediated suppression

Cited in

(25)

• Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response
• Modelling the suppression of autoimmunity after pathogen infection
• Mathematical methods and modeling of biophysical phenomena
• Sensibility of the quorum growth thresholds controlling local immune responses
• Autoimmunity arising from bystander proliferation of T cells in an immune response model
• Immune response dynamics
• A mathematical model of pancreatic cancer with two kinds of treatments
• A fit of CD4^+ T cell immune response to an infection by lymphocytic choriomeningitis virus
• A transcritical bifurcation in an immune response model
• Advantage of having regulatory T cells requires localized suppression of immune reactions
• Lifelong dynamics of human CD4\(^+\)CD25\(^+\) regulatory T cells: insights from \textit{in vivo} data and mathematical modeling
• A mathematical perspective on CD4\(^{+}\) T cell quorum-sensing
• Emergent group dynamics governed by regulatory cells produce a robust primary T cell response
• Optimal T cell cross-reactivity and the role of regulatory T cells
• Functional switching and stability of regulatory T cells
• Dynamics and biological thresholds
• Bifurcations and multistability in a model of cytokine-mediated autoimmunity
• Optimal number of regulatory T cells
• Time-delayed model of autoimmune dynamics
• Comparing antigen-independent mechanisms of T cell regulation
• Modeling regulation mechanisms in the immune system
• Mathematical modeling of allergy and specific immunotherapy: Th1-Th2-Treg interactions
• Stochastic dynamics in a time-delayed model for autoimmunity
• The role of the T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model
• Immune response model fitting to \(\mathrm{CD4^+}\) \(\mathrm{T}\) cell data in \textit{lymphocytic choriomeningitis virus} LCMV infection

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