Evolution on distributive lattices

DOI10.1016/J.JTBI.2006.03.013zbMATH Open1447.92269arXivq-bio/0511039OpenAlexW2013115302WikidataQ46231047 ScholiaQ46231047MaRDI QIDQ2201887FDOQ2201887

Nicholas Eriksson, Bernd Sturmfels, Niko Beerenwinkel

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: We consider the directed evolution of a population after an intervention that has significantly altered the underlying fitness landscape. We model the space of genotypes as a distributive lattice; the fitness landscape is a real-valued function on that lattice. The risk of escape from intervention, i.e., the probability that the population develops an escape mutant before extinction, is encoded in the risk polynomial. Tools from algebraic combinatorics are applied to compute the risk polynomial in terms of the fitness landscape. In an application to the development of drug resistance in HIV, we study the risk of viral escape from treatment with the protease inhibitors ritonavir and indinavir.

Full work available at URL: https://arxiv.org/abs/q-bio/0511039

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zbMATH Keywords

Bayesian networkfitness landscapedistributive latticeHIV drug resistancedirected evolutionchain polynomialmutagenetic treerisk polynomial

Mathematics Subject Classification ID

Problems related to evolution (92D15)

Cites Work

• Title not available (Why is that?)
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• Combinatorial Commutative Algebra
• Combinatorial landscapes
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• Counting linear extensions
• Generating Linear Extensions Fast
• On posets and Hopf algebras
• Evolutionary dynamics of invasion and escape
• Algebraic geometry of Bayesian networks
• An algorithm to generate all topological sorting arrangements
• A matrix for counting paths in acyclic digraphs
• Mutagenetic Tree Models

Cited In (3)

• Commutative algebra of statistical ranking
• Latent conjunctive Bayesian network: unify attribute hierarchy and Bayesian network for cognitive diagnosis
• Discrete max-linear Bayesian networks

Uses Software

• Mtreemix
• geno2pheno

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