Master equation approach to the assembly of viral capsids

DOI10.1016/J.JTBI.2006.04.023zbMATH Open1447.92305arXivq-bio/0508030OpenAlexW2090191818WikidataQ51939622 ScholiaQ51939622MaRDI QIDQ2201943FDOQ2201943

Authors: T. Keef, Cristian Micheletti, Reidun Twarock 

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: The distribution of inequivalent geometries occurring during self-assembly of the major capsid protein in thermodynamic equilibrium is determined based on a master equation approach. These results are implemented to characterize the assembly of SV40 virus and to obtain information on the putative pathways controlling the progressive build-up of the SV40 capsid. The experimental testability of the predictions is assessed and an analysis of the geometries of the assembly intermediates on the dominant pathways is used to identify targets for antiviral drug design.

Full work available at URL: https://arxiv.org/abs/q-bio/0508030

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zbMATH Keywords

master equationviral capsid assemblySV40 virus

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Protein sequences, DNA sequences (92D20)

Cites Work

• Mathematical models for tubular structures in the family of \textit{Papovaviridae}
• The Architecture of Viral Capsids Based on Tiling Theory
• A Stochastic Model of Icosahedral Capsid Growth
• A tiling approach to virus capsid assembly explaining a structural puzzle in virology

Cited In (16)

• Self-assembly of icosahedral viral capsids: the combinatorial analysis approach
• Group theory of icosahedral virus capsid vibrations: a top-down approach
• A mathematical-model approach to human population explosions caused by migration
• Biologic constraints on modelling virus assembly
• Pathway complexity of model virus capsid assembly systems
• Polyomaviridae assembly polymorphism from an energy landscape perspective
• SV40 assembly in vivo and in vitro
• Blueprints for viral capsids in the family of polyomaviridae
• Mathematical virology: a novel approach to the structure and assembly of viruses
• Assembly and Disassembly of Viral Capsids
• The Architecture of Viral Capsids Based on Tiling Theory
• A mathematical modeling approach to the formation of urban and rural areas: convergence of global solutions of the mixed problem for the master equation in sociodynamics
• An Equilibrium Assembly Model Applied to Murine Polyomavirus
• Mathematical modeling of HIV-like particle assembly \textit{in vitro}
• Kinetics of aggregation with a finite number of particles and application to viral capsid assembly
• Using computational approaches to study dengue virus capsid assembly

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