Dynamics, stability and inheritance of somatic DNA methylation imprints

DOI10.1016/J.JTBI.2006.05.012zbMATH Open1447.92156OpenAlexW2146962291WikidataQ51938790 ScholiaQ51938790MaRDI QIDQ2201974FDOQ2201974

Authors: Laura B. Sontag, Matthew C. Lorincz, E. G. Luebeck 

Publication date: 17 September 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2006.05.012

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zbMATH Keywords

bistabilityDNA methyltransferase (Dnmt)Markov chain modelhypomethylationCpG dinucleotide

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Cites Work

• Markov Chains

Cited In (4)

• Computation of epidemic final size distributions
• A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
• The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: phenotypic selection can occur with and without a downshift in promoter methylation status
• Competitive signal discrimination, methylation reprogramming and genomic imprinting

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