Dynamics, stability and inheritance of somatic DNA methylation imprints

DOI10.1016/J.JTBI.2006.05.012MaRDI QIDQ2201974zbMATH OpenOpenAlexWikidataFDO

Authors Laura B. Sontag, Matthew C. Lorincz, E. G. Luebeck

Publication date 17 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.05.012

zbMATH Keywords

bistabilityCpG dinucleotideDNA methyltransferase (Dnmt)hypomethylationMarkov chain model

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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Cites work

• Markov Chains

Cited in

(10)

• Inheritance of epigenetic chromatin silencing
• Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer
• Mathematical models of DNA methylation dynamics: implications for health and ageing
• The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: phenotypic selection can occur with and without a downshift in promoter methylation status
• Competitive signal discrimination, methylation reprogramming and genomic imprinting
• A mathematical model for inheritance of DNA methylation patterns in somatic cells
• Computation of epidemic final size distributions
• A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
• A stochastic automata network description for spatial DNA-methylation models
• A stochastic model for the formation of spatial methylation patterns

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