Dynamics, stability and inheritance of somatic DNA methylation imprints

DOI10.1016/J.JTBI.2006.05.012MaRDI QIDQ2201974zbMATHOpenAlexWikidataFDO

Authors Laura B. Sontag, Matthew C. Lorincz, E. G. Luebeck

Publication date 17 September 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2006.05.012

zbMATH Keywords

bistabilityDNA methyltransferase (Dnmt)Markov chain modelhypomethylationCpG dinucleotide

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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Cites work

• Markov Chains

Cited in

(10)

• A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
• A mathematical model for inheritance of DNA methylation patterns in somatic cells
• The influence of methylation status on a stochastic model of MGMT dynamics in glioblastoma: phenotypic selection can occur with and without a downshift in promoter methylation status
• Competitive signal discrimination, methylation reprogramming and genomic imprinting
• Inheritance of epigenetic chromatin silencing
• Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer
• Mathematical models of DNA methylation dynamics: implications for health and ageing
• A stochastic model for the formation of spatial methylation patterns
• Computation of epidemic final size distributions
• A stochastic automata network description for spatial DNA-methylation models

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