A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration
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Publication:2202437
DOI10.1016/J.APNUM.2020.08.004zbMATH Open1441.74267arXiv1903.09535OpenAlexW3048658356MaRDI QIDQ2202437FDOQ2202437
Authors: Laura Murphy, Anotida Madzvamuse 
Publication date: 18 September 2020
Published in: Applied Numerical Mathematics (Search for Journal in Brave)
Abstract: This work presents the development, analysis and numerical simulations of a biophysical model for 3D cell deformation and movement, which couples biochemical reactions and biomechanical forces. We propose a mechanobiochemical model which considers the actin filament network as a viscoelastic and contractile gel. The mechanical properties are modelled by a force balancing equation for the displacements, the pressure and concentration forces are driven by actin and myosin dynamics, and these are in turn modelled by a system of reaction-diffusion equations on a moving cell domain. The biophysical model consists of highly non-linear partial differential equations whose analytical solutions are intractable. To obtain approximate solutions to the model system, we employ the moving grid finite element method. The numerical results are supported by linear stability theoretical results close to bifurcation points during the early stages of cell migration. Numerical simulations exhibited show both simple and complex cell deformations in 3-dimensions that include cell expansion, cell protrusion and cell contraction. The computational framework presented here sets a strong foundation that allows to study more complex and experimentally driven reaction-kinetics involving actin, myosin and other molecular species that play an important role in cell movement and deformation.
Full work available at URL: https://arxiv.org/abs/1903.09535
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- scientific article; zbMATH DE number 1944194
cell motilitypartial differential equationsreaction-diffusion equationsviscoelasticmoving boundary problemmoving grid finite elementsforce balance equationmechanobiochemical model
Biomechanical solid mechanics (74L15) PDEs in connection with mechanics of deformable solids (35Q74) Finite element methods applied to problems in solid mechanics (74S05)
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- Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
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