A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration
From MaRDI portal
Publication:2202437
Abstract: This work presents the development, analysis and numerical simulations of a biophysical model for 3D cell deformation and movement, which couples biochemical reactions and biomechanical forces. We propose a mechanobiochemical model which considers the actin filament network as a viscoelastic and contractile gel. The mechanical properties are modelled by a force balancing equation for the displacements, the pressure and concentration forces are driven by actin and myosin dynamics, and these are in turn modelled by a system of reaction-diffusion equations on a moving cell domain. The biophysical model consists of highly non-linear partial differential equations whose analytical solutions are intractable. To obtain approximate solutions to the model system, we employ the moving grid finite element method. The numerical results are supported by linear stability theoretical results close to bifurcation points during the early stages of cell migration. Numerical simulations exhibited show both simple and complex cell deformations in 3-dimensions that include cell expansion, cell protrusion and cell contraction. The computational framework presented here sets a strong foundation that allows to study more complex and experimentally driven reaction-kinetics involving actin, myosin and other molecular species that play an important role in cell movement and deformation.
Recommendations
- The moving grid finite element method applied to cell movement and deformation
- Phase-field model of cellular migration: three-dimensional simulations in fibrous networks
- Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell
- Modeling cell movement and chemotaxis using pseudopod-based feedback
- scientific article; zbMATH DE number 1944194
Cites work
- scientific article; zbMATH DE number 48300 (Why is no real title available?)
- scientific article; zbMATH DE number 1218597 (Why is no real title available?)
- scientific article; zbMATH DE number 702824 (Why is no real title available?)
- A computational method for the coupled solution of reaction-diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis
- A continuum model of motility in ameboid cells
- A coupled bulk-surface model for cell polarisation
- A mathematical model for the dynamics of large membrane deformations of isolated fibroblasts
- A moving grid finite element method applied to a model biological pattern generator
- A robust and efficient adaptive multigrid solver for the optimal control of phase field formulations of geometric evolution laws
- Analysis of stable two-dimensional patterns in contractile cytogel
- Bayesian parameter identification for Turing systems on stationary and evolving domains
- Continuum modeling and numerical simulation of cell motility
- Cross-diffusion-driven instability for reaction-diffusion systems: analysis and simulations
- Elasticity and plasticity of large deformations.
- Finite element analysis for a coupled bulk-surface partial differential equation
- Finite elements on evolving surfaces
- GMRES: A Generalized Minimal Residual Algorithm for Solving Nonsymmetric Linear Systems
- Gmsh: a 3-D finite element mesh generator with built-in pre- and post-processing facilities
- Implicit-explicit methods for reaction-diffusion problems in pattern formation
- Implicit-explicit timestepping with finite element approximation of reaction-diffusion systems on evolving domains
- Lumped finite elements for reaction-cross-diffusion systems on stationary surfaces
- Mathematical methods for physicists. A comprehensive guide
- Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell
- Maximum principle in linear finite element approximations of anisotropic diffusion-convection-reaction problems
- Methods of conjugate gradients for solving linear systems
- Modeling cell movement and chemotaxis using pseudopod-based feedback
- Modeling of adhesion, protrusion, and contraction coordination for cell migration simulations
- Multiscale Two-Dimensional Modeling of a Motile Simple-Shaped Cell
- Nonlinear continuum mechanics and large inelastic deformations.
- Numerical recipes. The art of scientific computing.
- On preservation of positivity in some finite element methods for the heat equation
- Parameter identification through mode isolation for reaction-diffusion systems on arbitrary geometries
- Simulating biochemical signaling networks in complex moving geometries
- Stability analysis of non-autonomous reaction-diffusion systems: The effects of growing domains
- Symmetry breaking in a bulk-surface reaction-diffusion model for signalling networks
- The moving boundary node method: A level set-based, finite volume algorithm with applications to cell motility
- The moving grid finite element method applied to cell movement and deformation
- Time-stepping schemes for moving grid finite elements applied to reaction-diffusion systems on fixed and growing domains
Cited in
(10)- Phase-field model of cellular migration: three-dimensional simulations in fibrous networks
- Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
- Stability analysis for a new model of multi-species convection-diffusion-reaction in poroelastic tissue
- A biochemo-mechano coupled, computational model combining membrane transport and pericellular proteolysis in tissue mechanics
- Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell
- A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions
- Mathematical modeling of cell polarity establishment of budding yeast
- The Bulk-Surface Virtual Element Method for Reaction-Diffusion PDEs: Analysis and Applications
- The moving grid finite element method applied to cell movement and deformation
- A computational method for the coupled solution of reaction-diffusion equations on evolving domains and manifolds: application to a model of cell migration and chemotaxis
This page was built for publication: A moving grid finite element method applied to a mechanobiochemical model for 3D cell migration
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2202437)
