Stochastic Turing pattern formation in a model with active and passive transport

DOI10.1007/S11538-020-00822-YMaRDI QIDQ2211775zbMATH OpenOpenAlexWikidataFDO

Authors Hyunjoong Kim, Paul C. Bressloff

Publication date 13 November 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2009.06076

zbMATH Keywords

\textit{Caenorhabditis elegans}RDA master equationstochastic Turing pattern formationsynaptogenesis

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15)

Abstract: We investigate Turing pattern formation in a stochastic and spatially discretized version of a reaction diffusion advection (RDA) equation, which was previously introduced to model synaptogenesis in extit{C. elegans}. The model describes the interactions between a passively diffusing molecular species and an advecting species that switches between anterograde and retrograde motor-driven transport (bidirectional transport). Within the context of synaptogenesis, the diffusing molecules can be identified with the protein kinase CaMKII and the advecting molecules as glutamate receptors. The stochastic dynamics evolves according to an RDA master equation, in which advection and diffusion are both modeled as hopping reactions along a one-dimensional array of chemical compartments. Carrying out a linear noise approximation of the RDA master equation leads to an effective Langevin equation, whose power spectrum provides a means of extending the definition of a Turing instability to stochastic systems, namely, in terms of the existence of a peak in the power spectrum at a non-zero spatial frequency. We thus show how noise can significantly extend the range over which spontaneous patterns occur, which is consistent with previous studies of RD systems.

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Cites work

• A mechanism for Turing pattern formation with active and passive transport
• A theory of biological pattern formation
• A Turing model with correlated random walk
• Pattern Formation and Dynamics in Nonequilibrium Systems
• Stochastic pattern formation and spontaneous polarisation: the linear noise approximation and beyond
• Stochastic processes in cell biology
• The chemical basis of morphogenesis

Cited in

(4)

• Turing pattern formation under heterogeneous distributions of parameters for an activator-depleted reaction model
• A mechanism for Turing pattern formation with active and passive transport
• Bifurcation analysis and synapse pattern formation with bidirectional motor-mediated transports
• Pattern formation in agent-based and PDE models for evolutionary games with payoff-driven motion

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