Associative learning in biochemical networks

DOI10.1016/J.JTBI.2007.07.004zbMATH Open1453.92115arXivq-bio/0701010OpenAlexW2075737174WikidataQ48388134 ScholiaQ48388134MaRDI QIDQ2216264FDOQ2216264

Authors: Nikhil Gandhi, Gonen Ashkenasy, Emmanuel Tannenbaum 

Publication date: 15 December 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: We develop a simple, chemostat-based model illustrating how a process analogous to associative learning can occur in a biochemical network. Associative learning is a form of learning whereby a system "learns" to associate two stimuli with one another. In our model, two types of replicating molecules, denoted A and B, are present in some initial concentration in the chemostat. Molecules A and B are stimulated to replicate by some growth factors, denoted GA and GB, respectively. It is also assumed that A and B can covalently link, and that the conjugated molecule can be stimulated by either the GA or GB growth factors (and can be degraded). We show that, if the chemostat is stimulated by both growth factors for a certain time, followed by a time gap during which the chemostat is not stimulated at all, and if the chemostat is then stimulated again by only one of the growth factors, then there will be a transient increase in the number of molecules activated by the other growth factor. Therefore, the chemostat bears the imprint of earlier, simultaneous stimulation with both growth factors, which is indicative of associative learning. It is interesting to note that the dynamics of our model is consistent with various aspects of Pavlov's original series of associative learning experiments in dogs. We discuss how associative learning can potentially be performed in vitro within RNA, DNA, or peptide networks. We also highlight how such a mechanism could potentially be involved in genomic evolution, and suggest bioinformatics studies that could be used to find evidence for associative learning processes at work inside living cells.

Full work available at URL: https://arxiv.org/abs/q-bio/0701010

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zbMATH Keywords

biochemical networksassociative memoryRNA worldassociative learning

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Title not available (Why is that?)

Cited In (4)

• Can persistent Epstein-Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response?
• Towards a biomolecular learning machine
• Title not available (Why is that?)
• Associative pattern recognition through macro-molecular self-assembly

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