T cell development in the thymus: from periodic seeding to constant output

DOI10.1016/J.JTBI.2007.07.028zbMATH Open1453.92039OpenAlexW2081246106WikidataQ51905870 ScholiaQ51905870MaRDI QIDQ2216319FDOQ2216319

Authors: Anna Q. Cai, Kerry A. Landman, Barry D. Hughes, Colleen M. Witt 

Publication date: 15 December 2020

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2007.07.028

Recommendations

• Insights into the mechanisms of thymus involution and regeneration by modeling the glucocorticoid-induced perturbation of thymocyte populations dynamics
• A general mathematical method for investigating the thymic microenvironment, thymocyte development, and immunopathogeneisis
• Feedback loops, reversals and nonlinearities in lymphocyte development
• An improved model of T cell development in the thymus and its stability analysis
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zbMATH Keywords

differentiationproliferationperiodic oscillationsthymusthymocytes

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15) Cell biology (92C37)

Cites Work

• Oscillation and Chaos in Physiological Control Systems
• Feedback loops, reversals and nonlinearities in lymphocyte development
• An improved model of T cell development in the thymus and its stability analysis
• Estimation of the proliferation and maturation functions in a physiologically structured model of thymocyte development
• A general mathematical method for investigating the thymic microenvironment, thymocyte development, and immunopathogeneisis

Cited In (4)

• The type of seeder cells determines the efficiency of germinal center reactions
• The influence of T cell development on pathogen specificity and autoreactivity
• Insights into the mechanisms of thymus involution and regeneration by modeling the glucocorticoid-induced perturbation of thymocyte populations dynamics
• Dynamics of T cell receptor distributions following acute thymic atrophy and resumption

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