The adjustment of covariates in Cox's model under case-cohort design

DOI10.1155/2020/8884665MaRDI QIDQ2228155zbMATH OpenOpenAlexFDO

Authors G. Rong, Luwei Tang, Wenting Luo, Qing Li, Lifeng Deng

Publication date 16 February 2021

Published in Complexity (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2020/8884665

Mathematics Subject Classification ID

Nonparametric regression and quantile regression (62G08) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Review text

Summary: Case-cohort design is a biased sampling method. Due to its cost-effective and theoretical significance, this design has extensive application value in many large cohort studies. The case-cohort data includes a subcohort sampled randomly from the entire cohort and all the failed subjects outside the subcohort. In this paper, the adjustment for the distorted covariates is considered to case-cohort data in Cox's model. According to the existing adjustable methods of distorted covariates for linear and nonlinear models, we propose estimating the distorting functions by nonparametrically regressing the distorted covariates on the distorting factors; then, the estimators for the parameters are obtained using the estimated covariates. The proof of consistency and being asymptotically normal is completed. For calculating the maximum likelihood estimates of the regression coefficients subject in Cox's model, a minorization-maximization (MM) algorithm is developed. Simulation studies are performed to compare the estimations with the covariates undistorted, distorted, and adjusted to illustrate the proposed methods.

Recommendations

• Maximum Likelihood Estimation for Cox's Regression Model Under Case-Cohort Sampling
• Case-cohort and case-control analysis with Cox's model
• Case–Cohort Analysis with Accelerated Failure Time Model
• Stratified proportional subdistribution hazards model with covariate-adjusted censoring weight for case-cohort studies
• Generalized accelerated failure time model with censored data from case-cohort studies

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Cited in

(1)

• Research on covariate adjustment method based on proportional hazards model

Describes a project that uses

Uses Software

• bootstrap

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