Optimal control analysis of a leukemia model under Imatinib treatment

DOI10.1016/J.MATCOM.2015.03.002MaRDI QIDQ2228752zbMATH OpenOpenAlexFDO

Authors I. R. Rădulescu, D. Cândea, A. Halanay

Publication date 19 February 2021

Published in Mathematics and Computers in Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.matcom.2015.03.002

zbMATH Keywords

discretizationoptimal controlasymmetric divisiondelay differential systemleukemia

Mathematics Subject Classification ID

Functional-differential equations (including equations with delayed, advanced or state-dependent argument) (34Kxx) Physiological, cellular and medical topics (92Cxx)

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Cites work

• scientific article; zbMATH DE number 2062254 (Why is no real title available?)
• A Mathematical Study of the Hematopoiesis Process with Applications to Chronic Myelogenous Leukemia
• A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
• A mathematical model of hematopoiesis. I: Periodic chronic myelogenous leukemia
• A model of oscillatory blood cell counts in chronic myelogenous leukaemia
• Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls
• Drug resistance in cancer chemotherapy as an optimal control problem
• High frequency spikes in long period blood cell oscillations
• Long Period Oscillations in aG₀Model of Hematopoietic Stem Cells
• Numerical solution of optimal control problems with constant control delays
• Optimal control applied to immunotherapy
• Optimal control for resistance and suboptimal response in CML
• Optimal control of innate immune response
• Optimal control of treatment in a mathematical model of chronic myelogenous leukemia
• Oscillation and chaos in physiological control systems
• Relaxation Oscillations in a Class of Delay Differential Equations
• Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics

Cited in

(24)

• Optimal impulsive intervention strategy for target mRNA knockout in RNAi process
• Long-term treatment effects in chronic myeloid leukemia
• Progression, detection and remission: evolution of chronic myeloid leukemia using a three-stage probabilistic model
• A control delay differential equations model of evolution of normal and leukemic cell populations under treatment
• A quantitative study on the role of TKI combined with Wnt/\(\beta\)-catenin signaling and IFN-\(\alpha\) in the treatment of CML through deterministic and stochastic approaches
• Optimal control for a delay differential system of Chronic Myelogenous Leukemia
• An analysis of strategic treatment interruptions during imatinib treatment of chronic myelogenous leukemia with imatinib-resistant mutations
• A mathematical model with time-varying delays in the combined treatment of chronic myeloid leukemia
• Optimal control applied to a generalized Michaelis-Menten model of CML therapy
• An optimal treatment strategy for a leukemia immune model governed by reaction-diffusion equations
• Optimization of cytostatic leukemia therapy in an advection-reaction-diffusion model
• Stability and controllability issues in mathematical modeling of the intensive treatment of leukemia
• Optimal control for resistance and suboptimal response in CML
• New Computational Tools for Modeling Chronic Myelogenous Leukemia
• Optimization for the intensive treatment of leukemia
• Optimal control in a mathematical model for leukemia therapy with phase constraints
• Optimization of combined leukemia therapy by finite-dimensional optimal control modeling
• Mathematical analysis and optimal control applied to the treatment of leukemia
• A mathematical model of Imatinib and interferon-Alpha combined treatment of chronic myeloid leukemia
• On optimal and suboptimal treatment strategies for a mathematical model of leukemia
• Mathematical analysis and global dynamics for a time-delayed chronic myeloid leukemia model with treatment
• Chemo and immunotherapy effects on stability regions of tumor models
• Global stability analysis and optimal control therapy of blood cell production process (hematopoiesis) in acute myeloid leukemia
• Optimal control of treatment in a mathematical model of chronic myelogenous leukemia

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