Modifiers of mutation rate in selectively fluctuating environments

DOI10.1016/J.SPA.2020.06.011zbMATH Open1457.92124arXiv1909.06241OpenAlexW3041331464MaRDI QIDQ2229564FDOQ2229564

Authors: Elisabeth Sester-Huss, Peter Pfaffelhuber, Franz Baumdicker 

Publication date: 18 February 2021

Published in: Stochastic Processes and their Applications (Search for Journal in Brave)

Abstract: We study a mutation-selection model with a fluctuating environment. More precisely, individuals in a large population are assumed to have a modifier locus determining the mutation rate $uin[0,vartheta]$ at a second locus with types $vin[0,1]$. In addition, the environment fluctuates, meaning that individual types change their fitness at some high rate. Fitness only depends on the type of the second locus. We obtain general limit results for the evolution of the allele frequency distribution for rapidly fluctuating environments. As an application, we make use of the resulting Fleming-Viot process and compute the fixation probabilities for higher mutation rates in the special case of two bi-allelic loci in the limit of small fitness differences at the second locus.

Full work available at URL: https://arxiv.org/abs/1909.06241

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zbMATH Keywords

fixation probabilityFleming-Viot processmodifier theoryfluctuation selectionmicrobial evolutionsecond order evolution

Mathematics Subject Classification ID

Problems related to evolution (92D15) Functional limit theorems; invariance principles (60F17)

Cites Work

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• Probability Models for DNA Sequence Evolution
• Fleming–Viot Processes in Population Genetics
• Modifiers of mutation rate: A general reduction principle
• Scaling limits of population and evolution processes in random environment
• Temporal fluctuations in selection intensities: Case of small population size
• Tree-valued Fleming-Viot dynamics with mutation and selection
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• Environmental variation, fluctuating selection and genetic drift in subdivided populations

Cited In (6)

• The interaction between mobile DNAs and their hosts in a fluctuating environment
• Mutating away from your enemies: the evolution of mutation rate in a host-parasite system
• Evolution of transmission modifiers under frequency-dependent selection and transmission in constant or fluctuating environments
• The interaction of genetic drift and mutation with selection in a fluctuating environment
• Mutation rate evolution in replicator dynamics
• Life history and deleterious mutation rate coevolution

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