A simulation-extrapolation approach for the mixture cure model with mismeasured covariates
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Publication:2233552
DOI10.1214/21-EJS1874zbMATH Open1471.62483arXiv2009.06094OpenAlexW3183352882MaRDI QIDQ2233552FDOQ2233552
Eni Musta, Ingrid Van Keilegom
Publication date: 11 October 2021
Published in: Electronic Journal of Statistics (Search for Journal in Brave)
Abstract: We consider survival data from a population with cured subjects in the presence of mismeasured covariates. We use the mixture cure model to account for the individuals that will never experience the event and at the same time distinguish between the effect of the covariates on the cure probabilities and on survival times. In particular, for practical applications, it seems of interest to assume a logistic form of the incidence and a Cox proportional hazards model for the latency. To correct the estimators for the bias introduced by the measurement error, we use the simex algorithm, which is a very general simulation based method. It essentially estimates this bias by introducing additional error to the data and then recovers bias corrected estimators through an extrapolation approach. The estimators are shown to be consistent and asymptotically normally distributed when the true extrapolation function is known. We investigate their finite sample performance through a simulation study and apply the proposed method to analyse the effect of the prostate specific antigen (PSA) on patients with prostate cancer.
Full work available at URL: https://arxiv.org/abs/2009.06094
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Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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