Stochastic stem cell models with mutation: a comparison of asymmetric and symmetric divisions

DOI10.1016/J.MBS.2021.108541zbMATH Open1475.92031OpenAlexW3119531446MaRDI QIDQ2240239FDOQ2240239

Authors Zhijie Wu, Yuman Wang, Kun Wang, Da Zhou

Publication date 8 November 2021

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2010.03191

zbMATH Keywords

variancecancer dynamicscellular hierarchy

Mathematics Subject Classification ID

Developmental biology, pattern formation (92C15) Cell biology (92C37) Pathology, pathophysiology (92C32)

Abstract: In order to fulfill cell proliferation and differentiation through cellular hierarchy, stem cells can undergo either asymmetric or symmetric divisions. Recent studies pay special attention to the effect of different modes of stem cell division on the lifetime risk of cancer, and report that symmetric division is more beneficial to delay the onset of cancer. The fate uncertainty of symmetric division is considered to be the reason for the cancer-delaying effect. In this paper we compare asymmetric and symmetric divisions of stem cells via studying stochastic stem cell models with mutations. Specially, by using rigorous mathematical analysis we find that both asymmetric and symmetric models show the same statistical average, but symmetric model shows higher fluctuation than asymmetric model. We further show that the difference between the two models would be more remarkable for lower mutation rates. Our work quantifies the uncertainty of cell division and highlights the significance of stochasticity for distinguishing between different modes of stem cell division.

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Cites work

• scientific article; zbMATH DE number 3194920 (Why is no real title available?)
• A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells
• Concentration fluctuations in a mesoscopic oscillating chemical reaction system
• Dynamics of Cancer
• Handbook of stochastic methods for physics, chemistry and natural sciences.
• The phenotypic equilibrium of cancer cells: from average-level stability to path-wise convergence

Cited in

(6)

• Effects of asymmetric division on a stochastic model of the cell division cycle
• A cell model about symmetric and asymmetric stem cell division
• A stochastic model of neurogenesis controlled by a single factor
• Understanding stem cell differentiation through self-organization theory
• Stem cell regulation: implications when differentiated cells regulate symmetric stem cell division
• Optimal architecture of differentiation cascades with asymmetric and symmetric stem cell division

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