Modelling and direct numerical simulation of flow and solute dispersion in the spinal subarachnoid space

DOI10.1016/J.APM.2021.01.037zbMath1481.92038OpenAlexW3127838458MaRDI QIDQ2243404

W. Coenen, C. Gutiérrez-Montes, J. C. Lasheras, A. L. Sánchez, J. Josh Lawrence, Carlos Martínez-Bazán

Publication date: 11 November 2021

Published in: Applied Mathematical Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.apm.2021.01.037

zbMATH Keywords

cerebrospinal fluidintrathecal drug deliveryspinal canal

Mathematics Subject Classification ID

Physiological flows (76Z05) Physiological flow (92C35)

Related Items (4)

Buoyancy-modulated Lagrangian drift in wavy-walled vertical channels as a model problem to understand drug dispersion in the spinal canal ⋮ A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal ⋮ Stationary flow driven by non-sinusoidal time-periodic pressure gradients in wavy-walled channels ⋮ Effects of buoyancy on the dispersion of drugs released intrathecally in the spinal canal

Cites Work

• Solution of the implicitly discretized fluid flow equations by operator- splitting
• Computational fluid dynamics based dynamic modeling of parafoil system
• Cerebrospinal Fluid Mechanics and Its Coupling to Cerebrovascular Dynamics
• On the dispersion of a drug delivered intrathecally in the spinal canal
• On the bulk motion of the cerebrospinal fluid in the spinal canal

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