Perturbed factor analysis: accounting for group differences in exposure profiles

DOI10.1214/20-AOAS1435zbMATH Open1478.62342arXiv1910.03021OpenAlexW3204480679MaRDI QIDQ2247491FDOQ2247491

Authors: Arkaprava Roy, Isaac Lavine, Amy H. Herring, David Dunson 

Publication date: 17 November 2021

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: In this article, we investigate group differences in phthalate exposure profiles using NHANES data. Phthalates are a family of industrial chemicals used in plastics and as solvents. There is increasing evidence of adverse health effects of exposure to phthalates on reproduction and neuro-development, and concern about racial disparities in exposure. We would like to identify a single set of low-dimensional factors summarizing exposure to different chemicals, while allowing differences across groups. Improving on current multi-group additive factor models, we propose a class of Perturbed Factor Analysis (PFA) models that assume a common factor structure after perturbing the data via multiplication by a group-specific matrix. Bayesian inference algorithms are defined using a matrix normal hierarchical model for the perturbation matrices. The resulting model is just as flexible as current approaches in allowing arbitrarily large differences across groups but has substantial advantages that we illustrate in simulation studies. Applying PFA to NHANES data, we learn common factors summarizing exposures to phthalates, while showing clear differences across groups.

Full work available at URL: https://arxiv.org/abs/1910.03021

Recommendations

• Bayesian Factor Analysis for Inference on Interactions
• Multi‐study factor analysis
• Bayesian group factor analysis with structured sparsity
• Mixtures of multivariate restricted skew-normal factor analyzer models in a Bayesian framework
• Dynamic mixtures of factor analyzers to characterize multivariate air pollutant exposures

zbMATH Keywords

Bayesianfactor analysishierarchical modelperturbation matrixchemical mixturesmetaanalysisphthalate exposuresracial disparities

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Angle-based joint and individual variation explained
• Multi‐study factor analysis
• Sparse Bayesian infinite factor models
• Joint and individual variation explained (JIVE) for integrated analysis of multiple data types
• Title not available (Why is that?)
• Infinite mixtures of infinite factor analysers
• High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics
• Bayesian analysis of static and dynamic factor models: an ex-post approach towards the rotation problem
• Bayesian Factorizations of Big Sparse Tensors
• Clustering South African households based on their asset status using latent variable models
• A note on the multiplicative gamma process
• Bayesian Semiparametric Multivariate Density Deconvolution
• Incorporating covariates into integrated factor analysis of multi‐view data

Cited In (2)

• Bayesian combinatorial multistudy factor analysis
• Hierarchical resampling for bagging in multistudy prediction with applications to human neurochemical sensing

Uses Software

• RColorBrewer
• JIVE
• IMIFA
• MSFA

This page was built for publication: Perturbed factor analysis: accounting for group differences in exposure profiles

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2247491)