Perturbed factor analysis: accounting for group differences in exposure profiles

DOI10.1214/20-AOAS1435MaRDI QIDQ2247491zbMATHOpenAlexFDO

Authors Arkaprava Roy, Isaac Lavine, Amy H. Herring, David Dunson

Publication date 17 November 2021

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1910.03021

zbMATH Keywords

Bayesianfactor analysishierarchical modelperturbation matrixchemical mixturesmetaanalysisphthalate exposuresracial disparities

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In this article, we investigate group differences in phthalate exposure profiles using NHANES data. Phthalates are a family of industrial chemicals used in plastics and as solvents. There is increasing evidence of adverse health effects of exposure to phthalates on reproduction and neuro-development, and concern about racial disparities in exposure. We would like to identify a single set of low-dimensional factors summarizing exposure to different chemicals, while allowing differences across groups. Improving on current multi-group additive factor models, we propose a class of Perturbed Factor Analysis (PFA) models that assume a common factor structure after perturbing the data via multiplication by a group-specific matrix. Bayesian inference algorithms are defined using a matrix normal hierarchical model for the perturbation matrices. The resulting model is just as flexible as current approaches in allowing arbitrarily large differences across groups but has substantial advantages that we illustrate in simulation studies. Applying PFA to NHANES data, we learn common factors summarizing exposures to phthalates, while showing clear differences across groups.

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Cited in

(2)

• Bayesian combinatorial multistudy factor analysis
• Hierarchical resampling for bagging in multistudy prediction with applications to human neurochemical sensing

Describes a project that uses

Uses Software

• RColorBrewer
• JIVE
• IMIFA
• MSFA

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