Vertical modeling: analysis of competing risks data with a cure fraction

DOI10.1007/S10985-018-9417-8MaRDI QIDQ2274658zbMATH OpenOpenAlexWikidataFDO

Authors Mioara Alina Nicolaie, Catherine Legrand, Jeremy M. G. Taylor

Publication date 1 October 2019

Published in Lifetime Data Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1508.03821

zbMATH Keywords

competing risksmixture cure modelcumulative incidences

Mathematics Subject Classification ID

Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In this paper, we extend the vertical modeling approach for the analysis of survival data with competing risks to incorporate a cured fraction in the population, that is, a proportion of the population for which none of the competing events can occur. The proposed method has three components: the proportion of cure, the risk of failure, irrespective of the cause, and the relative risk of a certain cause of failure, given a failure occurred. Covariates may affect each of these components. An appealing aspect of the method is that it is a natural extension to competing risks of the semi-parametric mixture cure model in ordinary survival analysis; thus, causes of failure are assigned only if a failure occurs. This contrasts with the existing mixture cure model for competing risks of Larson and Dinse, which conditions at the onset on the future status presumably attained. Regression parameter estimates are obtained using an EM-algorithm. The performance of the estimators is evaluated in a simulation study. The method is illustrated using a melanoma cancer data set.

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Cited in

(6)

• Semiparametric estimation for proportional hazards mixture cure model allowing non-curable competing risk
• Gibbs Sampling for Long-Term Survival Data with Competing Risks
• Semiparametric mixture cure model analysis with competing risks data: application to vascular access thrombosis data
• A hidden competing risk model for censored observations
• A regression analysis of discrete time competing risks data using a vertical model approach
• A cure rate model for exponentially distributed lifetimes with competing risks

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