Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion

DOI10.1007/S10985-018-9445-4MaRDI QIDQ2274692zbMATH OpenOpenAlexWikidataFDO

Authors Yuan Wu, Christina D. Chambers, Ronghui Xu

Publication date 1 October 2019

Published in Lifetime Data Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1708.06838, http://europepmc.org/articles/pmc6335201

zbMATH Keywords

empirical processCox regressionspline functiongeneralized gradient projection algorithm

Mathematics Subject Classification ID

Nonparametric regression and quantile regression (62G08) Censored data models (62N01) Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: This work was motivated by observational studies in pregnancy with spontaneous abortion (SAB) as outcome. Clearly some women experience the SAB event but the rest do not. In addition, the data are left truncated due to the way pregnant women are recruited into these studies. For those women who do experience SAB, their exact event times are sometimes unknown. Finally, a small percentage of the women are lost to follow-up during their pregnancy. All these give rise to data that are left truncated, partly interval and right-censored, and with a clearly defined cured portion. We consider the non-mixture Cox regression cure rate model and adopt the semiparametric spline-based sieve maximum likelihood approach to analyze such data. Using modern empirical process theory we show that both the parametric and the nonparametric parts of the sieve estimator are consistent, and we establish the asymptotic normality for both parts. Simulation studies are conducted to establish the finite sample performance. Finally, we apply our method to a database of observational studies on spontaneous abortion.

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Cited in

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• Semiparametric regression analysis of length-biased and partly interval-censored data with application to an AIDS cohort study
• Maximum likelihood estimation for length-biased and interval-censored data with a nonsusceptible fraction
• Overview of recent advances on the analysis of interval-censored failure time data
• Semiparametric mixture cure model analysis with competing risks data: application to vascular access thrombosis data
• EM algorithm for the additive risk mixture cure model with interval-censored data
• Inference based on partly interval censored data from a two-parameter Rayleigh distribution
• Transformation models with informative partly interval-censored data
• Bayesian transformation models with partly interval-censored data
• Semiparametric regression analysis for left-truncated and interval-censored data without or with a cure fraction

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