How to correctly quantify neuronal phase-response curves from noisy recordings

DOI10.1007/S10827-019-00719-3zbMATH Open1427.92026DBLPjournals/jcns/HesseS19arXiv1901.04399OpenAlexW2963967159WikidataQ92973324 ScholiaQ92973324MaRDI QIDQ2280995FDOQ2280995

Authors: Janina Hesse, Susanne Schreiber 

Publication date: 19 December 2019

Published in: Journal of Computational Neuroscience (Search for Journal in Brave)

Abstract: At the level of individual neurons, various coding properties can be inferred from the input-output relationship of a cell. For small inputs, this relation is captured by the phase-response curve (PRC), which measures the effect of a small perturbation on the timing of the subsequent spike. Experimentally, however, an accurate experimental estimation of PRCs is challenging. Despite elaborate measurement efforts, experimental PRC estimates often cannot be related to those from modeling studies. In particular, experimental PRCs rarely resemble the generic PRC expected close to spike initiation, which is indicative of the underlying spike-onset bifurcation. Here, we show for conductance-based model neurons that the correspondence between theoretical and measured phase-response curve is lost when the stimuli used for the estimation are too large. In this case, the derived phase-response curve is distorted beyond recognition and takes on a generic shape that reflects the measurement protocol, but not the real neuronal dynamics. We discuss how to identify appropriate stimulus strengths for perturbation and noise-stimulation methods, which permit to estimate PRCs that reliably reflect the spike-onset bifurcation -- a task that is particularly difficult if a lower bound for the stimulus amplitude is dictated by prominent intrinsic neuronal noise.

Full work available at URL: https://arxiv.org/abs/1901.04399

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zbMATH Keywords

intrinsic noisefinite phase response curvephase response curve measurementspike onset bifurcation

Mathematics Subject Classification ID

Neural biology (92C20)

Cites Work

• Mathematical foundations of neuroscience
• On the Phase Reduction and Response Dynamics of Neural Oscillator Populations
• NEURAL EXCITABILITY, SPIKING AND BURSTING
• Chemical oscillations, waves, and turbulence
• Multiple pulse interactions and averaging in systems of coupled neural oscillators
• Computation of the Phase Response Curve: A Direct Numerical Approach
• Information filtering in resonant neurons
• Phase-response curves of ion channel gating kinetics
• Title not available (Why is that?)

Cited In (4)

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• The variance of phase-resetting curves
• Phase-response curves of ion channel gating kinetics
• Stimulus features, resetting curves, and the dependence on adaptation

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