Fully nonparametric estimation of the marginal survival function based on case-control clustered data

DOI10.1214/19-EJS1651zbMATH Open1444.62117arXiv1812.00641OpenAlexW2997328955MaRDI QIDQ2283582FDOQ2283582

Authors: David M. Zucker, M. Gorfine 

Publication date: 3 January 2020

Published in: Electronic Journal of Statistics (Search for Journal in Brave)

Abstract: A case-control family study is a study where individuals with a disease of interest (case probands) and individuals without the disease (control probands) are randomly sampled from a well-defined population. Possibly right-censored age at onset and disease status are observed for both probands and their relatives. Correlation among the outcomes within a family is induced by factors such as inherited genetic susceptibility, shared environment, and common behavior patterns. For this setting, we present a nonparametric estimator of the marginal survival function, based on local linear estimation of conditional survival functions. Asymptotic theory for the estimator is provided, and simulation results are presented showing that the method performs well. The method is illustrated on data from a prostate cancer study. Keywords: case-control; family study; multivariate survival; nonparametric estimator; local linear

Full work available at URL: https://arxiv.org/abs/1812.00641

Recommendations

• Nonparametric hypothesis testing in clustered survival model
• Semiparametric analysis of clustered survival data under nonparametric frailty
• Non-parametric Bayesian analysis of clustered survival data
• A nonparametric frailty model for clustered survival data
• Nonparametric survival function estimation for data subject to interval censoring case 2
• A fully nonparametric approach in survival models with explanatory variables
• On Non-parametric Estimation of the Survival Function with Competing Risks
• Fitting marginal accelerated failure time models to clustered survival data with potentially informative cluster size

zbMATH Keywords

nonparametric estimatorlocal linearcase-controlmultivariate survival datafamily study

Mathematics Subject Classification ID

Density estimation (62G07) Asymptotic properties of nonparametric inference (62G20) Estimation in survival analysis and censored data (62N02) Estimation in multivariate analysis (62H12)

Cites Work

• Asymptotic Statistics
• Rates of strong uniform consistency for multivariate kernel density estimators. (Vitesse de convergence uniforme presque sûre pour des estimateurs à noyaux de densités multivariées)
• Title not available (Why is that?)
• Cox's regression model for counting processes: A large sample study
• Uniform Central Limit Theorems
• Title not available (Why is that?)
• Nearest neighbor estimates of regression
• Estimation of a Probability Density Function and Its Derivatives
• Case–Control and Case‐Only Designs with Genotype and Family History Data: Estimating Relative Risk, Residual Familial Aggregation, and Cumulative Risk
• Analysis of survival data from case-control family studies

Cited In (3)

• Semiparametric Estimation of Marginal Hazard Function from Case-Control Family Studies
• Case-control current status data
• On estimation of the hazard function from population-based case-control studies

This page was built for publication: Fully nonparametric estimation of the marginal survival function based on case-control clustered data

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2283582)