Stochastic modeling and dynamic analysis of the cardiovascular system with rotary left ventricular assist devices

DOI10.1155/2019/7179317zbMATH Open1435.92012arXiv1812.07157OpenAlexW2903904337MaRDI QIDQ2298735FDOQ2298735

Authors: Jeongeun Son, Dongping Du, Yuncheng Du 

Publication date: 20 February 2020

Published in: Mathematical Problems in Engineering (Search for Journal in Brave)

Abstract: The left ventricular assist device (LVAD) has been used for end-stage heart failure patients as a therapeutic option. The aortic valve plays a critical role in heart failure and its treatment with LVAD. The cardiovascular-LVAD model is often used to investigate the physiological demands required by patients and predict the hemodynamic of the native heart supported with a LVAD. As a bridge to recovery treatment, it is important to maintain appropriate and active dynamics of the aortic valve and the cardiac output of the native heart, which requires that the LVAD pump must be adjusted so that a proper balance between the blood contributed through the aortic valve and the pump is maintained. In this paper, our objective is to identify a critical value of the pump power to ensure that the LVAD pump does not take over the pumping function in the cardiovascular-pump system and share the ejected blood with left ventricle to help the heart to recover. In addition, hemodynamic often involves variability due to patients heterogeneity and the stochastic nature of cardiovascular system. The variability poses significant challenges to understand dynamic behaviors of the aortic valve and cardiac output. A generalized polynomial chaos (gPC) expansion is used in this work to develop a stochastic cardiovascular-pump model for efficient uncertainty propagation, from which it is possible to rapidly calculate the variance in the aortic valve opening duration and the cardiac output in the presence of variability. The simulation results show that the gPC based cardiovascular-pump model is a reliable platform that can provide useful information to understand the effect of LVAD pump on the hemodynamic of the heart.

Full work available at URL: https://arxiv.org/abs/1812.07157

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Mathematics Subject Classification ID

Physiology (general) (92C30) Biomechanics (92C10)

Cites Work

• Numerical methods for stochastic computations. A spectral method approach.
• A new control system for left ventricular assist devices based on patient-specific physiological demand

Cited In (4)

• Analysis of the impact of left ventricular assist devices on the systemic circulation
• Heart rhythm analysis using a nonlinear dynamics perspective
• Corrigendum to: ``Stochastic modeling and dynamic analysis of the cardiovascular system with rotary left ventricular assist devices
• Rotary heart assist devices

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