Maternal passive immunity and dengue hemorrhagic fever in infants

DOI10.1007/S11538-020-00699-XMaRDI QIDQ2299340zbMATH OpenOpenAlexWikidataFDO

Authors Diego Samuel Rodrigues, Fernando L. P. Santos, Mostafa Adimy, Paulo F. A. Mancera, Cláudia P. Ferreira

Publication date 21 February 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-020-00699-x

zbMATH Keywords

antibody-dependent enhancement (ADE)DENVlocal and global stability analysesmathematical modeling

Mathematics Subject Classification ID

Stability of solutions to ordinary differential equations (34D20) Global stability of solutions to ordinary differential equations (34D23) Epidemiology (92D30)

Review text

This paper studies a mathematical model assessing the role of maternal dengue-specific antibodies in the development of dengue hemorrhagic fever in infants. The model accounts for the biological mechanisms behind the antibody-dependent enhancement phenomena in infants and it describes some features including the initial concentration of maternal antibodies received by the infant at born, the strength of the competition between virus neutralization and infection enhancement promoted by antibody as well as the virus capability of infecting cells. It is shown that the solution are nonnegative and bounded on the interval \([0,+\infty)\). The existence of the equilibria of the system is discussed including local and global asymptotic stability stability of the disease-free steady state, and local asymptotic stability of the dengue hemorrhagic fever steady state. The disease-free steady is shown to be locally asymptotically stable if the basic reproduction is less than 1 and unstable if it is larger than 1. Numerical simulations are also provided to validate the theoretical results.

Recommendations

• A mathematical model to describe antibody-dependent enhancement and assess the effect of limiting cloning for plasma cells in heterologous secondary dengue infection
• A mathematical model to evaluate the role of memory B and T cells in heterologous secondary dengue infection
• A simple mathematical model to describe antibody-dependent enhancement in heterologous secondary infection in dengue
• Cross immunity protection and antibody-dependent enhancement in a distributed delay dynamic model
• Mathematical model of the immune response to dengue virus

Cites work

• A simple mathematical model to describe antibody-dependent enhancement in heterologous secondary infection in dengue
• scientific article; zbMATH DE number 1598672 (Why is no real title available?)
• scientific article; zbMATH DE number 1324225 (Why is no real title available?)
• Mathematical modeling on T-cell mediated adaptive immunity in primary dengue infections
• On comparison systems for ordinary differential equations
• Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission
• The role of antibody in enhancing dengue virus infection

Cited in

(6)

• Modeling the relationship between antibody-dependent enhancement and disease severity in secondary dengue infection
• Dengue fever spreading based on probabilistic cellular automata with two lattices
• Dynamical analysis of secondary dengue viral infection with multiple target cells and diffusion by mathematical model
• A Mathematical Model for Accessing Dengue Hemorrhagic Fever in Infants
• A CONTINUOUS SPATIAL AND TEMPORAL MATHEMATICAL MODEL FOR ASSESSING THE DISTRIBUTION OF DENGUE IN BRAZIL WITH CONTROL
• Multi-serotype nested immuno-epidemiological model for dengue hemorrhagic fever involving backward bifurcation and serotype invasion

This page was built for publication: Maternal passive immunity and dengue hemorrhagic fever in infants

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2299340)