Bautin bifurcation in a minimal model of immunoediting

DOI10.3934/DCDSB.2019233MaRDI QIDQ2301346zbMATH OpenOpenAlexWikidataFDO

Authors Joaquin Delgado, Eymard Hernández-López, L. I. Hernández-Martínez

Publication date 24 February 2020

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1807.00953

zbMATH Keywords

Bautin bifurcationcancer modelingimmunoediting

Mathematics Subject Classification ID

Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Qualitative investigation and simulation of ordinary differential equation models (34C60) Cell biology (92C37)

Abstract: One of the simplest model of immune surveillance and neoplasia was proposed by Delisi and Resigno. Later Liu et al proved the existence of non-degenerate Takens-Bogdanov bifurcations defining a surface in the whole set of five positive parameters. In this paper we prove the existence of Bautin bifurcations completing the scenario of possible codimension two bifurcations that occur in this model. We give an interpretation of our results in terms of the three phases immunoediting theory:elimination, equilibrium and escape.

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Cites work

• Bifurcation analysis in models of tumor and immune system interactions
• Effects of vascularization on lymphocyte/tumor cell dynamics: Qualitative features
• Elements of applied bifurcation theory.
• Immune surveillance and neoplasia. I: A minimal mathematical model
• Initialization of homoclinic solutions near Bogdanov-Takens points: Lindstedt-Poincaré compared with regular perturbation method
• Numerical analysis of homoclinic orbits emanating from a Takens-Bogdanov point
• NUMERICAL DETECTION AND CONTINUATION OF CODIMENSION-TWO HOMOCLINIC BIFURCATIONS
• Predator-prey equations simulating an immune response

Cited in

(4)

• Stochastic simulation on a minimal model of cancer immunoediting theory
• Backward bifurcation in neutrophil-pathogen interaction
• Bifurcations in a cancer and immune model with Allee effect
• Mathematical modeling of Allee effects in tumor dynamics: insights into chemotherapy and immunotherapy optimization

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