On finite volume discretization of infiltration dynamics in tumor growth models

DOI10.1007/S10444-019-09727-4MaRDI QIDQ2305561zbMATH OpenOpenAlexWikidataFDO

Authors Mashriq Ahmed Saleh, Jianjun Paul Tian, Xianyi Zeng

Publication date 11 March 2020

Published in Advances in Computational Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1809.00466

zbMATH Keywords

cell incompressibilityfinite volume methodsfree boundary problemsPatlak-Keller-Segel systemtumor growth modeling

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Finite volume methods for initial value and initial-boundary value problems involving PDEs (65M08) Cell biology (92C37)

Abstract: We address numerical challenges in solving hyperbolic free boundary problems described by spherically symmetric conservation laws that arise in the modeling of tumor growth due to immune cell infiltrations. In this work, we normalize the radial coordinate to transform the free boundary problem to a fixed boundary one, and utilize finite volume methods to discretize the resulting equations. We show that the conventional finite volume methods fail to preserve constant solutions and the incompressibility condition, and they typically lead to inaccurate, if not wrong, solutions even for very simple tests. These issues are addressed in a new finite volume framework with segregated flux computations that satisfy sufficient conditions for ensuring the so-called totality conservation law and the geometric conservation law. Classical first-order and second-order finite volume methods are enhanced in this framework. Their performance is assessed by various benchmark tests to show that the enhanced methods are able to preserve the incompressibility constraint and produce much more accurate results than the conventional ones.

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Cited in

(4)

• Finite-element approximation of a phase field model for tumour growth
• Finite element approximation of a Keller-Segel model with additional self- and cross-diffusion terms and a logistic source
• Convergence of numerical schemes for convection-diffusion-reaction equations on generic meshes
• A gradient discretisation method for anisotropic reaction-diffusion models with applications to the dynamics of brain tumors

Describes a project that uses

Uses Software

• Chemotaxis

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